Fleroxacin resistance in Escherichia coli.
作者信息
Chapman J S, Bertasso A, Georgopapadakou N H
机构信息
Roche Research Center, Nutley, New Jersey 07110.
出版信息
Antimicrob Agents Chemother. 1989 Feb;33(2):239-41. doi: 10.1128/AAC.33.2.239.
Abstract
Spontaneous fleroxacin-resistant mutants of Escherichia coli K-12 were isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plated. All mutants exhibited quinolone-resistant replicative DNA biosynthesis, and 4 of 11 mutants also had decreased amounts of OmpF or OmpC porin. None of the mutants had changes solely in porin proteins.
摘要
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