阿米氟沙星对明确的耐庆大霉素革兰氏阴性菌的活性。
Amifloxacin activity against well-defined gentamicin-resistant, gram-negative bacteria.
作者信息
John J F, Twitty J A
出版信息
Antimicrob Agents Chemother. 1984 Nov;26(5):781-4. doi: 10.1128/AAC.26.5.781.
Abstract
Amifloxacin (WIN 49375) activity against a well-defined group of gentamicin-resistant gram-negative bacilli was compared with the activity of 11 other antimicrobial agents. For all strains, amifloxacin and norfloxacin were the most active agents, followed by cefotaxime and moxalactam. For Acinetobacter sp. only amifloxacin had an achievable MIC for 90% of the strains. Amifloxacin joins other newly developed DNA gyrase inhibitors as potentially useful agents for infections due to aminoglycoside-resistant gram-negative bacilli.
摘要
将阿米氟沙星（WIN 49375）对一组明确的耐庆大霉素革兰氏阴性杆菌的活性与其他11种抗菌药物的活性进行了比较。对于所有菌株，阿米氟沙星和诺氟沙星是活性最强的药物，其次是头孢噻肟和拉氧头孢。对于不动杆菌属，只有阿米氟沙星对90%的菌株有可达到的最低抑菌浓度（MIC）。阿米氟沙星与其他新开发的DNA旋转酶抑制剂一样，是治疗由耐氨基糖苷类革兰氏阴性杆菌引起的感染的潜在有用药物。
相似文献
1
Amifloxacin activity against well-defined gentamicin-resistant, gram-negative bacteria.阿米氟沙星对明确的耐庆大霉素革兰氏阴性菌的活性。
Antimicrob Agents Chemother. 1984 Nov;26(5):781-4. doi: 10.1128/AAC.26.5.781.
2
Antibacterial activity of amifloxacin (WIN 49, 375), a new quinolone agent.
Diagn Microbiol Infect Dis. 1985 Nov;3(6):469-78. doi: 10.1016/s0732-8893(85)80003-1.
3
In vitro comparison of amifloxacin and six other antibiotics against aminoglycoside-resistant Pseudomonas aeruginosa.阿米氟沙星与其他六种抗生素对氨基糖苷类耐药铜绿假单胞菌的体外比较
Antimicrob Agents Chemother. 1984 Aug;26(2):275-6. doi: 10.1128/AAC.26.2.275.
4
5
In vitro evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones.A-56619（二氟沙星）和A-56620：新型芳基氟喹诺酮类药物的体外评价
Antimicrob Agents Chemother. 1986 Feb;29(2):193-200. doi: 10.1128/AAC.29.2.193.
6
Susceptibility of non-fermentative gram-negative bacteria to ciprofloxacin, norfloxacin, amifloxacin, pefloxacin and cefpirome.非发酵革兰氏阴性菌对环丙沙星、诺氟沙星、阿米氟沙星、培氟沙星和头孢匹罗的敏感性。
J Antimicrob Chemother. 1986 Dec;18(6):675-9. doi: 10.1093/jac/18.6.675.
7
Comparative antimicrobial activity of enoxacin, ciprofloxacin, amifloxacin, norfloxacin and ofloxacin against 177 bacterial isolates.依诺沙星、环丙沙星、阿米氟沙星、诺氟沙星和氧氟沙星对177株细菌分离株的抗菌活性比较
J Antimicrob Chemother. 1986 May;17(5):623-8. doi: 10.1093/jac/17.5.623.
8
In vitro activity of ciprofloxacin compared with other agents against recent hospital isolates.环丙沙星与其他药物对近期医院分离株的体外活性比较。
Chemioterapia. 1986 Apr;5(2):75-82.
9
In vitro activity of A-56619 and A56620, two new aryl-fluoroquinolone antimicrobial agents.两种新型芳基氟喹诺酮类抗菌剂A-56619和A-56620的体外活性
Antimicrob Agents Chemother. 1986 Feb;29(2):355-8. doi: 10.1128/AAC.29.2.355.
10
In vitro activities of amifloxacin and two of its metabolites.阿米氟沙星及其两种代谢物的体外活性。
Antimicrob Agents Chemother. 1989 May;33(5):762-6. doi: 10.1128/AAC.33.5.762.
引用本文的文献
1
Fluorinated quinolones. A review of their mode of action, antimicrobial activity, pharmacokinetics and clinical efficacy.氟喹诺酮类。对其作用方式、抗菌活性、药代动力学及临床疗效的综述。
Pharm Weekbl Sci. 1986 Feb 21;8(1):1-21. doi: 10.1007/BF01975473.
2
Fluoroquinolone antimicrobial agents.氟喹诺酮类抗菌剂。
Clin Microbiol Rev. 1989 Oct;2(4):378-424. doi: 10.1128/CMR.2.4.378.
3
In vitro activity of amifloxacin against outer membrane mutants of the family Enterobacteriaceae and frequency of spontaneous resistance.阿米氟沙星对肠杆菌科外膜突变体的体外活性及自发耐药频率
Antimicrob Agents Chemother. 1989 Nov;33(11):1837-40. doi: 10.1128/AAC.33.11.1837.
本文引用的文献
1
Characteristics of Serratia marcescens containing a plasmid coding for gentamicin resistance in nosocomial infections.医院感染中携带编码庆大霉素耐药质粒的粘质沙雷氏菌的特征
J Infect Dis. 1981 Jun;143(6):810-7. doi: 10.1093/infdis/143.6.810.
2
Rapid procedure for detection and isolation of large and small plasmids.用于检测和分离大小质粒的快速方法。
J Bacteriol. 1981 Mar;145(3):1365-73. doi: 10.1128/jb.145.3.1365-1373.1981.
3
In vitro susceptibilities of 393 recent clinical isolates to WIN 49375, cefotaxime, tobramycin, and piperacillin.393株近期临床分离株对WIN 49375、头孢噻肟、妥布霉素和哌拉西林的体外药敏试验结果。
Antimicrob Agents Chemother. 1984 Mar;25(3):377-9. doi: 10.1128/AAC.25.3.377.
4
Positively supercoiled plasmid DNA is produced by treatment of Escherichia coli with DNA gyrase inhibitors.通过用DNA回旋酶抑制剂处理大肠杆菌可产生正超螺旋质粒DNA。
Nucleic Acids Res. 1983 May 25;11(10):2999-3017. doi: 10.1093/nar/11.10.2999.
5
Escherichia coli DNA topoisomerase I mutants: increased supercoiling is corrected by mutations near gyrase genes.大肠杆菌DNA拓扑异构酶I突变体：超螺旋增加可通过gyrase基因附近的突变得到纠正。
Cell. 1982 Nov;31(1):35-42. doi: 10.1016/0092-8674(82)90402-0.
6
Comparative activities of ciprofloxacin (Bay o 9867), norfloxacin, pipemidic acid, and nalidixic acid.环丙沙星（拜奥9867）、诺氟沙星、吡哌酸和萘啶酸的比较活性。
Antimicrob Agents Chemother. 1983 Aug;24(2):302-4. doi: 10.1128/AAC.24.2.302.
7
In vitro activity of ciprofloxacin, norfloxacin and nalidixic acid.环丙沙星、诺氟沙星和萘啶酸的体外活性。
Eur J Clin Microbiol. 1983 Apr;2(2):111-5. doi: 10.1007/BF02001575.
8
Bactericidal activity of norfloxacin and nine other urinary tract antibiotics against Gram-negative bacilli causing bacteriuria in chronically catheterized patients.诺氟沙星及其他九种泌尿道抗生素对慢性导尿患者引起菌尿的革兰氏阴性杆菌的杀菌活性。
J Antimicrob Chemother. 1983 Mar;11(3):287-90. doi: 10.1093/jac/11.3.287.
9
[Comparative study of six quinolone antibacterials (author's transl)].六种喹诺酮类抗菌药物的比较研究（作者译）
Ann Microbiol (Paris). 1977 Jul;128B(1):19-33.
10
A rapid alkaline extraction procedure for screening recombinant plasmid DNA.一种用于筛选重组质粒DNA的快速碱性提取方法。
Nucleic Acids Res. 1979 Nov 24;7(6):1513-23. doi: 10.1093/nar/7.6.1513.
Zotero 插件