阿米氟沙星对明确的耐庆大霉素革兰氏阴性菌的活性。
Amifloxacin activity against well-defined gentamicin-resistant, gram-negative bacteria.
作者信息
John J F, Twitty J A
出版信息
Antimicrob Agents Chemother. 1984 Nov;26(5):781-4. doi: 10.1128/AAC.26.5.781.
Abstract
Amifloxacin (WIN 49375) activity against a well-defined group of gentamicin-resistant gram-negative bacilli was compared with the activity of 11 other antimicrobial agents. For all strains, amifloxacin and norfloxacin were the most active agents, followed by cefotaxime and moxalactam. For Acinetobacter sp. only amifloxacin had an achievable MIC for 90% of the strains. Amifloxacin joins other newly developed DNA gyrase inhibitors as potentially useful agents for infections due to aminoglycoside-resistant gram-negative bacilli.
摘要
将阿米氟沙星（WIN 49375）对一组明确的耐庆大霉素革兰氏阴性杆菌的活性与其他11种抗菌药物的活性进行了比较。对于所有菌株，阿米氟沙星和诺氟沙星是活性最强的药物，其次是头孢噻肟和拉氧头孢。对于不动杆菌属，只有阿米氟沙星对90%的菌株有可达到的最低抑菌浓度（MIC）。阿米氟沙星与其他新开发的DNA旋转酶抑制剂一样，是治疗由耐氨基糖苷类革兰氏阴性杆菌引起的感染的潜在有用药物。
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