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基于醌的聚合物在无标记和无试剂电化学免疫传感器中的应用：在蛋白质、抗体和农药检测中的应用。

Quinone-based polymers for label-free and reagentless electrochemical immunosensors: application to proteins, antibodies and pesticides detection.

机构信息

Université Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR 7086 CNRS, 15 rue J-A de Baïf, 75205 Paris Cedex 13, France; E-Mails:

Université Paris XI, INSERM U-1014, Groupe Hospitalier Paul Brousse-94800 Villejuif, France; E-Mail:

出版信息

Biosensors (Basel). 2013 Jan 14;3(1):58-76. doi: 10.3390/bios3010058. eCollection 2013 Mar.

DOI:10.3390/bios3010058
PMID:25587398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4263589/
Abstract

Polyquinone derivatives are widely recognized in the literature for their remarkable properties, their biocompatibility, simple synthesis, and easy bio-functionalization. We have shown that polyquinones present very stable electroactivity in neutral aqueous medium within the cathodic potential domain avoiding side oxidation of interfering species. Besides, they can act as immobilized redox transducers for probing biomolecular interactions in sensors. Our group has been working on devices based on such modified electrodes with a view to applications for proteins, antibodies and organic pollutants using a reagentless label-free electrochemical immunosensor format. Herein, these developments are briefly reviewed and put into perspective.

摘要

多醌衍生物因其显著的性质、生物相容性、简单的合成和易于生物功能化而在文献中得到广泛认可。我们已经表明，多醌在中性水性介质中的阴极电位范围内具有非常稳定的电活性，避免了干扰物质的副氧化。此外，它们可以作为固定化氧化还原转导体，用于传感器中探测生物分子相互作用。我们的研究小组一直在研究基于这种修饰电极的设备，以期在无试剂的电化学免疫传感器格式中应用于蛋白质、抗体和有机污染物。本文简要回顾了这些发展，并展望了未来的前景。

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