Johansson E, Halldin M M, Agurell S, Hollister L E, Gillespie H K
Department of Pharmacognosy, Uppsala University, Sweden.
Eur J Clin Pharmacol. 1989;37(3):273-7. doi: 10.1007/BF00679783.
The terminal elimination half-life of delta 1-tetrahydrocannabinol (delta 1-THC) was investigated in eight men who were heavy users of marijuana. A stable isotope assay, following smoking deuterium-labeled delta 1-THC, was used to determine plasma concentrations. In two additional users plasma levels were followed after administration of unlabeled delta 1-THC. The subjects were asked to smoke a "loading dose" of 56 mg delta 1-THC during two days and then abstain from all marijuana use for 4 weeks. The pharmacokinetic behavior was consistent with a multicompartment model with a mean plasma elimination half-life of delta 1-THC of 4.3 days when concentrations were followed for 10-15 days after smoking. In the two subjects with detectable plasma levels during 4 weeks, half-lives of 9.6 and 12.6 days was obtained.
对八名重度大麻使用者的男性进行了δ1-四氢大麻酚（δ1-THC）的终末消除半衰期研究。在吸食氘标记的δ1-THC后，采用稳定同位素分析法测定血浆浓度。在另外两名使用者中，给予未标记的δ1-THC后监测血浆水平。受试者被要求在两天内吸食56毫克δ1-THC的“负荷剂量”，然后在4周内停止使用所有大麻。药代动力学行为符合多室模型，吸食后10 - 15天监测浓度时，δ1-THC的平均血浆消除半衰期为4.3天。在4周内血浆水平可检测的两名受试者中，半衰期分别为9.6天和12.6天。
