淋巴细胞维生素C水平作为帕金森病进展的潜在生物标志物。

Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease.

作者信息

Ide Kazuki, Yamada Hiroshi, Umegaki Keizo, Mizuno Katsuki, Kawakami Nobuko, Hagiwara Yuka, Matsumoto Mizuki, Yoshida Hidefumi, Kim Kang, Shiosaki Emi, Yokochi Tsunehiro, Harada Kiyoshi

机构信息

Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan; Department of Neurology, Shizuoka General Hospital, Shizuoka, Japan.

出版信息

Nutrition. 2015 Feb;31(2):406-8. doi: 10.1016/j.nut.2014.08.001. Epub 2014 Aug 23.

DOI:10.1016/j.nut.2014.08.001

PMID:25592020

Abstract

OBJECTIVES

Vitamin C is a major antioxidant and also is known as a neuromodulator in dopaminergic neurons. The aim of this study was to investigate the association between lymphocyte and plasma vitamin C levels in various stages of Parkinson's disease (PD).

METHODS

Sixty-two individuals with PD (age 71 ± 8.8 y [mean ± SD]) being treated at Shizuoka General Hospital from December 2007 to August 2013 were consecutively recruited. PD severity was classified using the Hoehn-Yahr scale for staging PD. Fasting blood samples were collected, and plasma and lymphocyte vitamin C levels were measured. The association between PD severity and vitamin C levels was estimated by ordinal logistic regression with confounding variables.

RESULTS

The distribution of Hoehn-Yahr stages in patients was as follows: stage I, 7; II, 28; III, 16; and IV, 11. Lymphocyte vitamin C levels in patients with severe PD were significantly lower (odds ratio [OR], 0.87; 95% confidence interval [CI], 0.80-0.97; P < 0.01) compared with those at less severe stages. Plasma vitamin C levels also tended to be lower in patients with severe PD; however, this was not significant (OR, 0.98; 95% CI, 0.96-1.00; P = 0.09).

CONCLUSIONS

Our findings suggest that lymphocyte vitamin C levels in the peripheral blood may be a potentially useful biomarker for the progression of PD.

摘要

目的

维生素C是一种主要的抗氧化剂，在多巴胺能神经元中也被认为是一种神经调节剂。本研究旨在探讨帕金森病（PD）不同阶段淋巴细胞和血浆维生素C水平之间的关联。

方法

连续招募了2007年12月至2013年8月在静冈综合医院接受治疗的62例PD患者（年龄71±8.8岁[平均值±标准差]）。使用Hoehn-Yahr量表对PD严重程度进行分期。采集空腹血样，测定血浆和淋巴细胞维生素C水平。通过有序逻辑回归分析混杂变量，估计PD严重程度与维生素C水平之间的关联。

结果

患者的Hoehn-Yahr分期分布如下：I期7例；II期28例；III期16例；IV期11例。与病情较轻阶段的患者相比，重度PD患者的淋巴细胞维生素C水平显著降低（优势比[OR]，0.87；95%置信区间[CI]，0.80-0.97；P<0.01）。重度PD患者的血浆维生素C水平也往往较低；然而，这并不显著（OR，0.98；95%CI，0.96-1.00；P=0.09）。