Wang Zhihua, Wang Yibin
From the Molecular Biology Institute, Cardiovascular Research Laboratories, Departments of Anesthesiology, Physiology, and Medicine, David Geffen School of Medicine, University of California at Los Angeles.
Circ Res. 2015 Jan 16;116(2):235-6. doi: 10.1161/CIRCRESAHA.114.305490.
Myheart is a cardiac specific long-noncoding (lnc) RNA with targeted modulation of chromatin modifying SWI/SNF complex via direct interaction with Brg1. Genetic induction of Myheart in mouse heart has a significant protective effect against the pathogenesis of heart failure. LncRNAs are emerging epigenetic regulators with potentially important roles in cardiac development and diseases.
Myheart是一种心脏特异性长链非编码（lnc）RNA，通过与Brg1直接相互作用对染色质修饰SWI/SNF复合体进行靶向调控。在小鼠心脏中基因诱导Myheart对心力衰竭的发病机制具有显著的保护作用。长链非编码RNA是新兴的表观遗传调节因子，在心脏发育和疾病中可能发挥重要作用。
