Mohammadi Zahed, Giardino Luciano, Palazzi Flavio, Asgary Saeed
Iranian Center for Endodontic Research, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; ; Iranian National Elites Foundation, Tehran, Iran;
Department of Periodontology, Endodontology, Pharmacology and Microbiology, Dental School, University of Brescia, Italy;
Iran Endod J. 2015 Winter;10(1):1-5. Epub 2014 Dec 24.
Root canal irrigants play a significant role in elimination of the microorganisms, tissue remnants, and removal of the debris and smear layer. No single solution is able to fulfill all these actions completely; therefore, a combination of irrigants may be required. The aim of this investigation was to review the agonistic and antagonistic interactions between chlorhexidine (CHX) and other irrigants and medicaments. An English-limited Medline search was performed for articles published from 2002 to 2014. The searched keywords included: chlorhexidine AND sodium hypochlorite/ethylenediaminetetraacetic acid/calcium hydroxide/mineral trioxide aggregate. Subsequently, a hand search was carried out on the references of result articles to find more matching papers. Findings showed that the combination of CHX and sodium hypochlorite (NaOCl) causes color changes and the formation of a neutral and insoluble precipitate; CHX forms a salt with ethylenediaminetetraacetic acid (EDTA). In addition, it has been demonstrated that the alkalinity of calcium hydroxide (CH) remained unchanged after mixing with CHX. Furthermore, mixing CHX with CH may enhance its antimicrobial activity; also mixing mineral trioxide aggregate (MTA) powder with CHX increases its antimicrobial activity but this may negatively affect its mechanical properties.
根管冲洗剂在清除微生物、组织残渣以及去除碎屑和玷污层方面发挥着重要作用。没有单一的溶液能够完全实现所有这些作用；因此，可能需要多种冲洗剂联合使用。本研究的目的是综述洗必泰（CHX）与其他冲洗剂和药物之间的协同和拮抗相互作用。对2002年至2014年发表的文章进行了英文文献检索范围有限的医学文献数据库（Medline）检索。检索关键词包括：洗必泰与次氯酸钠/乙二胺四乙酸/氢氧化钙/三氧化矿物凝聚体。随后，对检索结果文章的参考文献进行了手工检索，以找到更多匹配的论文。研究结果表明，洗必泰与次氯酸钠（NaOCl）混合会导致颜色变化并形成一种中性且不溶性沉淀；洗必泰与乙二胺四乙酸（EDTA）形成盐。此外，已证明氢氧化钙（CH）与洗必泰混合后碱度保持不变。此外，洗必泰与氢氧化钙混合可能会增强其抗菌活性；将三氧化矿物凝聚体（MTA）粉末与洗必泰混合也会增加其抗菌活性，但这可能会对其机械性能产生负面影响。
