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牙髓病学中的冲洗:聚己缩胍是根管治疗中一种有前景的抗菌聚合物。

Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment.

作者信息

Khabadze Zurab, Generalova Yulia, Kulikova Alena, Podoprigora Irina, Abdulkerimova Saida, Bakaev Yusup, Makeeva Mariya, Dashtieva Marina, Balashova Mariya, Gadzhiev Fakhri, Mordanov Oleg, Umarov Adam, Tarik Haddad, Zoryan Andrei, Karnaeva Amina, Rakhmanov Yakup

机构信息

Department of Operative Dentistry, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow 117198, Russia.

出版信息

Dent J (Basel). 2023 Mar 1;11(3):65. doi: 10.3390/dj11030065.

DOI:10.3390/dj11030065
PMID:36975562
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10047796/
Abstract

BACKGROUND

chronic apical periodontitis is a common pathology in dentistry, especially in endodontics. It is necessary to systematize data concerning commonly used irrigation solutions. The development of new protocols for endodontic treatment is a very promising direction. The use of a polyhexanide-based antiseptic can positively affect the results of endodontic treatment.

METHODS

the review was carried out involving the search for English language research and meta-analyses in the Google Scholar and PubMed databases.

RESULTS

the number of literary sources that were identified during the literature review is 180. After excluding publications that did not match the search criteria, the total number of articles included in the systematic review was determined to be 68.

CONCLUSIONS

polyhexanide is a promising solution for infected root canal irrigation. The antibacterial activity of this substance is suitable for the elimination of pathogens responsible for the appearance of apical periodontitis.

摘要

背景

慢性根尖周炎是牙科领域,尤其是牙髓病学中常见的病理状况。有必要对常用冲洗液的数据进行系统化整理。开发新的牙髓治疗方案是一个非常有前景的方向。使用基于聚己缩胍的防腐剂可对牙髓治疗结果产生积极影响。

方法

通过在谷歌学术和PubMed数据库中搜索英文研究和荟萃分析进行本综述。

结果

在文献综述过程中识别出的文献来源数量为180篇。排除不符合搜索标准的出版物后,确定纳入系统评价的文章总数为68篇。

结论

聚己缩胍是用于感染根管冲洗的一种有前景的溶液。该物质的抗菌活性适用于消除导致根尖周炎的病原体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ac/10047796/9fb74ef44295/dentistry-11-00065-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ac/10047796/9fb74ef44295/dentistry-11-00065-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ac/10047796/9fb74ef44295/dentistry-11-00065-g001.jpg

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本文引用的文献

1
Fungal cell barriers and organelles are disrupted by polyhexamethylene biguanide (PHMB).多聚六亚甲基双胍(PHMB)破坏真菌的细胞屏障和细胞器。
Sci Rep. 2023 Feb 16;13(1):2790. doi: 10.1038/s41598-023-29756-w.
2
Effectiveness of polyhexamethylene biguanide, chlorhexidine, and calcium hydroxide intracanal medicament against intraradicular mature polymicrobial biofilm: A microbiological study.聚六亚甲基双胍、氯己定和氢氧化钙根管内药物对根管内成熟多微生物生物膜的有效性:一项微生物学研究。
J Conserv Dent. 2022 Sep-Oct;25(5):536-540. doi: 10.4103/jcd.jcd_288_22. Epub 2022 Sep 12.
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Polyhexamethylene biguanide hydrochloride (PHMB)-properties and application of an antiseptic agent. A narrative review.
聚六亚甲基双胍盐酸盐(PHMB)——一种防腐剂的特性与应用。一篇叙述性综述。
Eur J Ophthalmol. 2022 Sep 9:11206721221124684. doi: 10.1177/11206721221124684.
4
Biofilm in Endodontics: In Vitro Cultivation Possibilities, Sonic-, Ultrasonic- and Laser-Assisted Removal Techniques and Evaluation of the Cleaning Efficacy.牙髓病学中的生物膜:体外培养可能性、声波、超声和激光辅助清除技术以及清洁效果评估
Polymers (Basel). 2022 Mar 25;14(7):1334. doi: 10.3390/polym14071334.
5
Utility of investigation for suspected microbial keratitis: a diagnostic accuracy study.疑似微生物角膜炎的检查效用:一项诊断准确性研究。
Eye (Lond). 2023 Feb;37(3):415-420. doi: 10.1038/s41433-022-01952-4. Epub 2022 Jan 31.
6
Mechanical, antibacterial, biocompatible and microleakage evaluation of glass ionomer cement modified by nanohydroxyapatite/polyhexamethylene biguanide.纳米羟磷灰石/聚六亚甲基双胍改性玻璃离子水门汀的机械性能、抗菌性能、生物相容性和微渗漏评价。
Dent Mater J. 2022 Apr 1;41(2):197-208. doi: 10.4012/dmj.2021-096. Epub 2021 Nov 11.
7
Fabrication of collagen with polyhexamethylene biguanide: A potential scaffold for infected wounds.聚六亚甲基双胍与胶原蛋白的制备:一种用于感染伤口的潜在支架
J Biomed Mater Res B Appl Biomater. 2022 Mar;110(3):535-546. doi: 10.1002/jbm.b.34933. Epub 2021 Sep 3.
8
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BMC Urol. 2021 Apr 9;21(1):58. doi: 10.1186/s12894-021-00826-3.
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Effect of Polyhexamethylene Biguanide in Combination with Undecylenamidopropyl Betaine or PslG on Biofilm Clearance.聚六亚甲基双胍与十一碳烯酰胺丙基甜菜碱或PslG联合使用对生物膜清除的影响。
Int J Mol Sci. 2021 Jan 14;22(2):768. doi: 10.3390/ijms22020768.
10
Filling the Void: An Optimized Polymicrobial Interkingdom Biofilm Model for Assessing Novel Antimicrobial Agents in Endodontic Infection.填补空白:一种用于评估牙髓感染中新型抗菌剂的优化多微生物跨界生物膜模型
Microorganisms. 2020 Dec 14;8(12):1988. doi: 10.3390/microorganisms8121988.