Tangney Christy C
Department of Clinical Nutrition, Rush University Medical Center, 1700 W Van Buren St Suite 425 TOB, Chicago, IL 60612, T: 312-942-5995, F: 312-942-5203.
Curr Nutr Rep. 2014 Mar 1;3(1):51-61. doi: 10.1007/s13668-013-0070-2.
There is growing consensus that as the US population ages, nearly a third will experience stroke, dementia or even both. Thus, interest in the role that diet may play in preserving cognitive abilities continues to grow especially in absence of truly effective treatments for dementia, of which Alzheimer's disease (AD) is the most common form. The purpose of this review is to examine whether two dietary patterns influence the rate of cognitive decline or the onset of dementia. Evidence from neuropathology reports of those who have died with AD or with mild cognitive impairment (MCI) or without cognitive impairment suggests that often the pathological hallmarks of AD---amyloid deposition and presence of tangles are present along with vascular lesions. Hypertension and stroke are strongly associated with incident dementia. Thus, it is possible that lifestyle approaches designed to prevent or reduce cardiovascular risk factors, conditions or diseases may also provide added benefits for brain health.
人们越来越一致地认为,随着美国人口老龄化,近三分之一的人将经历中风、痴呆症,甚至两者皆有。因此,对于饮食在保持认知能力方面可能发挥的作用的兴趣持续增长,尤其是在缺乏针对痴呆症的真正有效治疗方法的情况下,阿尔茨海默病(AD)是最常见的痴呆症形式。本综述的目的是研究两种饮食模式是否会影响认知能力下降的速度或痴呆症的发病。来自死于AD、轻度认知障碍(MCI)或无认知障碍者的神经病理学报告的证据表明,AD的病理特征——淀粉样蛋白沉积和缠结的存在通常与血管病变同时出现。高血压和中风与新发痴呆症密切相关。因此,旨在预防或降低心血管危险因素、病症或疾病的生活方式方法也可能对大脑健康带来额外益处。