Koc Emine Rabia, Ersoy Alevtina, Ilhan Atilla, Erken Haydar Ali, Sahın Semsettin
Department of Neurology, Faculty of Medicine, Balıkesir University, Balıkesir, Turkey.
Noise Health. 2015 Jan-Feb;17(74):11-6. doi: 10.4103/1463-1741.149565.
Noise, one of the main components of modern society, has become an important environmental problem. Noise is not only an irritating sound, but also a stress factor leading to serious health problems. In this study, we have investigated possible effects of rosuvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, thought to have an antioxidant effect, on noise-induced oxidative stress in the serum of rat models. Thirty-two male Wistar albino rats were used. In order to ease their adaptation, 2 weeks before the experiment, the rats were divided into four groups (with eight rats per each group): Noise exposure plus rosuvastatin usage, only noise exposure, only rosuvastatin usage and control. After the data had been collected, oxidant (Malondialdehyde, nitric oxide [NO], protein carbonyl [PC]) and antioxidant (superoxide dismutase [SOD], glutathione peroxidase [GSH-PX], catalase [CAT]) parameters were analyzed in the serum. Results indicated that SOD values were found to be significantly lower, while PC values in serum were remarkably higher in the group that was exposed to only noise. GSH-Px values in serum dramatically increased in the group on which only rosuvastatin was used. During noise exposure, the use of rosuvastatin caused significantly increased CAT values, whereas it resulted in reduced PC and NO values in serum. In conclusion, our data show that noise exposure leads to oxidative stress in rat serum; however, rosuvastatin therapy decreases the oxidative stress caused by noise exposure.
噪声作为现代社会的主要组成部分之一，已成为一个重要的环境问题。噪声不仅是一种令人烦躁的声音，还是导致严重健康问题的压力因素。在本研究中，我们调查了瑞舒伐他汀（一种3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂，被认为具有抗氧化作用）对大鼠模型血清中噪声诱导的氧化应激的可能影响。使用了32只雄性Wistar白化大鼠。为了便于它们适应，在实验前2周，将大鼠分为四组（每组8只）：噪声暴露加使用瑞舒伐他汀组、仅噪声暴露组、仅使用瑞舒伐他汀组和对照组。收集数据后，分析血清中的氧化剂（丙二醛、一氧化氮[NO]、蛋白质羰基[PC]）和抗氧化剂（超氧化物歧化酶[SOD]、谷胱甘肽过氧化物酶[GSH-PX]、过氧化氢酶[CAT]）参数。结果表明，仅暴露于噪声的组中SOD值显著降低，而血清中的PC值显著升高。仅使用瑞舒伐他汀的组中血清GSH-Px值显著增加。在噪声暴露期间，使用瑞舒伐他汀导致CAT值显著增加，而血清中的PC和NO值降低。总之，我们的数据表明，噪声暴露会导致大鼠血清中的氧化应激；然而，瑞舒伐他汀治疗可降低噪声暴露引起的氧化应激。
