Cormack M A, Owens R G, Dewey M E
J R Coll Gen Pract. 1989 Oct;39(327):408-11.
Seventy one long-term users of benzodiazepines were asked by their general practitioners in a letter or short interview to reduce their medication. Twenty two patients were successful in giving up or reducing their consumption to less than 100 tablets per annum. There were no clear predictors of success in terms of patient characteristics, duration of drug use, type of benzodiazepine, reason for drug use or strategy employed to reduce medication. However, patients who were successful at reducing their medication had a significantly lower mean baseline drug consumption than unsuccessful patients. The implications of this study are that a proportion of long-term users who are not in current crisis, especially those with relatively low consumption, can reduce or stop benzodiazepine treatment with minimal difficulty.
71名长期使用苯二氮䓬类药物的患者被他们的全科医生通过信件或简短访谈要求减少用药量。22名患者成功停药或将用药量减少至每年少于100片。就患者特征、用药时长、苯二氮䓬类药物类型、用药原因或减少用药所采用的策略而言,没有明确的成功预测因素。然而,成功减少用药量的患者其平均基线药物消费量显著低于未成功的患者。这项研究的意义在于,一部分当前没有处于危机状态的长期使用者,尤其是那些用药量相对较低的人,可以在最小困难的情况下减少或停止苯二氮䓬类药物治疗。