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全科医生进行简短干预以减少苯二氮䓬类药物长期使用的对照评估。

Controlled evaluation of brief intervention by general practitioners to reduce chronic use of benzodiazepines.

作者信息

Bashir K, King M, Ashworth M

机构信息

Academic Department of Psychiatry, Royal Free Hospital School of Medicine, London.

出版信息

Br J Gen Pract. 1994 Sep;44(386):408-12.

Abstract

BACKGROUND

It is recommended that long-term users of benzodiazepines in general practice be withdrawn from their medication where possible.

AIM

A study was undertaken to assess the effectiveness of minimal intervention delivered by general practitioners in helping chronic users of benzodiazepines to withdraw from their medication, and to determine the psychological sequelae on patients of such intervention.

METHOD

Patients taking benzodiazepines regularly for at least one year were recruited by their general practitioner and allocated either to a group receiving brief advice during one consultation supplemented by a self-help booklet or to a control group who received routine care. The patients completed the 12-item general health questionnaire and a benzodiazepine withdrawal symptom questionnaire at the outset of the study and at three and six months after this.

RESULTS

Eighteen per cent of patients in the intervention group (9/50) had a reduction in benzodiazepine prescribing recorded in the notes compared with 5% of the 55 patients in the control group (P < 0.05). In the intervention group, 63% of patients had a score of two or more on the general health questionnaire at baseline compared with 52% at six months. Of the 20 intervention patients reporting benzodiazepine reduction, 60% had a score of two or more at baseline compared with 40% at six months. Intervention patients had significantly more qualitative, but not quantitative, withdrawal symptoms at six months compared with baseline. Consultation rates were not increased in the intervention group.

CONCLUSION

The study indicates that some chronic users can successfully reduce their intake of benzodiazepines with simple advice from the general practitioner and a self-help booklet. This type of intervention does not lead to psychological distress or increased consultation.

摘要

背景

一般建议在全科医疗中,长期使用苯二氮䓬类药物的患者应尽可能停药。

目的

开展一项研究,以评估全科医生进行的最小干预措施在帮助苯二氮䓬类药物慢性使用者停药方面的有效性,并确定此类干预措施对患者的心理后遗症。

方法

由全科医生招募定期服用苯二氮䓬类药物至少一年的患者,并将其分配到一组,该组在一次会诊中接受简短建议并辅以一本自助手册,或分配到接受常规护理的对照组。患者在研究开始时以及此后的三个月和六个月时完成12项一般健康问卷和苯二氮䓬类药物戒断症状问卷。

结果

干预组中有18%的患者(9/50)在记录中显示苯二氮䓬类药物的处方量减少,而对照组的55名患者中这一比例为5%(P<0.05)。在干预组中,63%的患者在基线时一般健康问卷的得分在两分及以上,而六个月时这一比例为52%。在报告苯二氮䓬类药物用量减少的20名干预组患者中,60%在基线时得分在两分及以上,而六个月时这一比例为40%。与基线相比,干预组患者在六个月时出现的定性而非定量的戒断症状明显更多。干预组的会诊率没有增加。

结论

该研究表明,一些慢性使用者在全科医生的简单建议和一本自助手册的帮助下,可以成功减少苯二氮䓬类药物的摄入量。这种干预措施不会导致心理困扰或会诊增加。

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