Jędrasik-Styła Małgorzata, Ciołkiewicz Agnieszka, Styła Rafał, Linke Magdalena, Parnowska Dorota, Gruszka Anna, Denisiuk Mirella, Jarema Marek, Green Michael F, Wichniak Adam
Third Department of Psychiatry, Institute of Psychiatry and Neurology, Sobieskiego 9 Street, 02-957, Warsaw, Poland,
Psychiatr Q. 2015 Sep;86(3):435-47. doi: 10.1007/s11126-015-9343-9.
Work and social functioning in schizophrenia are strongly influenced by cognitive impairment so improving cognition is a priority in the treatment of schizophrenia. Until recently the lack of a widely accepted index of cognitive change for use in schizophrenia was a major obstacle to the development of cognition enhancing treatments. The MATRICS (measurement and treatment research to improve cognition in schizophrenia) consensus cognitive battery (MCCB) was developed as a standard cognitive battery for use in clinical trials of cognition enhancing treatments for schizophrenia and has attracted worldwide interest. To analyze the reliability and validity of a translated and adapted Polish approved academic version of the MCCB. Sixty one patients were assessed at baseline and again after 30 days. The study protocol approximated the MATRICS psychometric and standardization study; the 10 tests that comprise the MCCB were administered to participants. Functioning and psychopathological symptoms were also assessed. Patients and test administrators also assessed the tolerability and practicality of all the cognitive tests. All tests in the battery were found to have high test-retest reliability. All the tests were rated as tolerable and practical by patients and administrators. However practice effects were generally higher in the Polish version of the MCCB than in the original version. Our analysis corroborates previous evidence that the MCCB represents a good tool for assessing cognitive deficits in research studies of schizophrenia also in non-English speaking countries.
精神分裂症患者的工作和社交功能受到认知障碍的强烈影响,因此改善认知是精神分裂症治疗的首要任务。直到最近,缺乏一个被广泛接受的用于精神分裂症认知变化的指标,一直是认知增强治疗发展的主要障碍。精神分裂症认知改善测量与治疗研究(MATRICS)共识认知成套测验(MCCB)被开发出来,作为用于精神分裂症认知增强治疗临床试验的标准认知成套测验,并引起了全球关注。分析经翻译和改编的波兰语批准学术版MCCB的信度和效度。61名患者在基线时接受评估,并在30天后再次评估。研究方案近似于MATRICS心理测量和标准化研究;对参与者进行了构成MCCB的10项测试。还评估了功能和精神病理症状。患者和测试管理人员也评估了所有认知测试的耐受性和实用性。发现成套测验中的所有测试都具有较高的重测信度。患者和管理人员将所有测试评为可耐受且实用。然而,MCCB波兰语版的练习效应通常高于原版。我们的分析证实了先前的证据,即MCCB是评估精神分裂症研究中认知缺陷的良好工具,在非英语国家也是如此。