O'Sullivan David, Pearce Erika L
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Trends Immunol. 2015 Feb;36(2):71-80. doi: 10.1016/j.it.2014.12.004. Epub 2015 Jan 15.
In the past several years a wealth of evidence has emerged illustrating how metabolism supports many aspects of T cell biology, as well as how metabolic changes drive T cell differentiation and fate. We outline developing principles in the regulation of T cell metabolism, and discuss how these processes are affected in settings of inflammation and cancer. In this context we discuss how metabolic pathways might be manipulated for the treatment of human disease, including how metabolism may be targeted to prevent T cell dysfunction in inhospitable microenvironments, to generate more effective adoptive cellular immunotherapies in cancer, and to direct T cell differentiation and function towards non-pathogenic phenotypes in settings of autoimmunity.
在过去几年中，大量证据表明新陈代谢如何支持T细胞生物学的多个方面，以及代谢变化如何驱动T细胞分化和命运。我们概述了T细胞代谢调节中的发展原则，并讨论了这些过程在炎症和癌症环境中是如何受到影响的。在此背景下，我们讨论了如何操纵代谢途径来治疗人类疾病，包括如何针对代谢以防止T细胞在恶劣微环境中功能失调，如何在癌症中产生更有效的过继性细胞免疫疗法，以及如何在自身免疫环境中将T细胞分化和功能导向非致病性表型。
