脊髓损伤患者的血清可溶性CD95配体浓度
Serum sCD95L concentration in patients with spinal cord injury.
作者信息
Biglari Bahram, Büchler Axel, Swing Tyler, Child Christopher, Biehl Elisabeth, Reitzel Tim, Bruckner Tom, Ferbert Thomas, Korff Sebastian, Rief Harald, Gerner Hans-Jürgen, Moghaddam Arash
机构信息
BG Trauma Centre Ludwigshafen, Department of Paraplegiology, Ludwigshafen, Germany.
Heidelberg Trauma Research Group, Trauma and Reconstructive Surgery, Department of Orthopaedics, Traumatology, and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany
出版信息
J Int Med Res. 2015 Apr;43(2):250-6. doi: 10.1177/0300060514559794. Epub 2015 Jan 19.
OBJECTIVE
To determine serum concentrations of soluble CD95 ligand (sCD95L) in patients with traumatic spinal cord injury.
METHODS
Patients with traumatic spinal cord injury were recruited. Blood was collected on admission to hospital and at 4 h, 9 h, 12 h, 24 h, 3 days, 7 days, and 2, 4, 8 and 12 weeks postadmission. Serum concentrations of sCD95L were determined via immunoassay.
RESULT
The study included 23 patients. Mean sCD95L concentrations were significantly lower at 4 h, 9 h, 12 h and 24 h than at admission, and were significantly higher at 8 and 12 weeks, compared with admission.
CONCLUSION
The serum sCD95L concentration fell significantly during the first 24 h after traumatic spinal cord injury. Concentrations then rose, becoming significantly higher than admission levels at 8 weeks. sCD95L may represent a possible therapeutic target for traumatic spinal cord injury.
目的
测定创伤性脊髓损伤患者血清中可溶性CD95配体（sCD95L）的浓度。
方法
招募创伤性脊髓损伤患者。在入院时以及入院后4小时、9小时、12小时、24小时、3天、7天以及2周、4周、8周和12周采集血液。通过免疫测定法测定血清中sCD95L的浓度。
结果
该研究纳入了23例患者。4小时、9小时、12小时和24小时时的平均sCD95L浓度显著低于入院时，与入院时相比，8周和12周时显著升高。
结论
创伤性脊髓损伤后最初24小时内血清sCD95L浓度显著下降。随后浓度上升，在8周时显著高于入院水平。sCD95L可能是创伤性脊髓损伤的一个潜在治疗靶点。
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