脊髓损伤的潜在生物标志物：简要综述
Promising Biomarkers for Spinal Cord Injury: A Brief Review.
作者信息
Singh Anita
机构信息
Associate Professor, Bioengineering, Temple University, PA, USA.
出版信息
Curr Trends Biomed Eng Biosci. 2024;22(4). doi: 10.19080/ctbeb.2024.22.556095. Epub 2023 Apr 25.
Abstract
Mechanical trauma to the spinal cord leads to neural and molecular pathophysiological responses. Biomarkers are emerging as a promising unbiased tool that can assess the pathophysiological processes following spinal cord injury (SCI). In this concise review, we provide details of role and expression of structural, including Neurofilament Proteins (NF), Glial Fibrillary Acidic Protein (GFAP), Cleaved Tau (C-Tau), S100-β, Neuron Specific Enolase (NSE), Myelin Basic Protein (MBP), and inflammatory, including Transforming Growth Factor Beta (TGF-β), Tumor Necrosis Factor (TNF), Interleukins (ILs), Soluble CD95 Ligand (sCD95L) biomarkers in reported human and animal SCI studies.
摘要
脊髓的机械性创伤会引发神经和分子病理生理反应。生物标志物正成为一种有前景的客观工具，可用于评估脊髓损伤（SCI）后的病理生理过程。在这篇简要综述中，我们详细介绍了在已报道的人类和动物SCI研究中，结构生物标志物（包括神经丝蛋白（NF）、胶质纤维酸性蛋白（GFAP）、裂解型tau蛋白（C-Tau）、S100-β、神经元特异性烯醇化酶（NSE）、髓鞘碱性蛋白（MBP））以及炎症生物标志物（包括转化生长因子β（TGF-β）、肿瘤坏死因子（TNF）、白细胞介素（ILs）、可溶性CD95配体（sCD95L））的作用和表达情况。
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