Cai Da, Li Danlei, Zhao Shancang, Dou Xiaowei, Wang Fang, Huang Guohong, Zhao Mouming, Li Quanyang
College of Light Industry and Food Engineering, Guangxi University, Nanning, 530004, China.
Biol Trace Elem Res. 2015 May;165(1):18-29. doi: 10.1007/s12011-015-0233-7. Epub 2015 Jan 21.
Monitoring the element concentrations in the human body is of critical importance for health and longevity. In order to explore the formation mechanism of longevity from the perspective of the body's element loads, this study investigated the prominent feature of element profiles in healthy people over 80 years from Bama County (China), a famous longevous region (LR). The element profiles in nails of elderly people from the LR and a non-longevous region were determined by inductively coupled plasma mass spectrometry, using orthogonal projections to latent structures discriminant analysis (OPLS-DA) for pattern recognition. As a result, four characteristic elements closely related to the healthy elderly people from LR, including Cr, Fe, Mn, and Co, were identified. The concentrations of Cr, Fe, Mn, and Co were significantly increased in the LR group (p < 0.05). The values of fold change of Cr, Fe, Mn, and Co were 3.00, 2.46, 2.24, and 2.21, respectively. These characteristic elements could provide an important material guarantee for health and longevity of elderly people in the LR. The further correlation analysis revealed significant positive correlations between the Sr (r = 0.886), Mn (r = 0.873), Ni (r = 0.786), and Co (r = 0.738) concentrations in nails of elderly people and those in drinking water. Furthermore, significant positive correlations were found between the Se (r = 0.940), Mn (r = 0.833), and Fe (r = 0.733) concentrations in nails and their dietary intake. Consequently, the observations suggested that diet could provide extraordinary reference information in terms of reflecting the feature of element profiles in healthy elderly people over 80 years from the LR.
监测人体中的元素浓度对健康和长寿至关重要。为了从人体元素负荷的角度探索长寿的形成机制，本研究调查了来自中国著名长寿地区巴马县80岁以上健康人群的元素谱特征。采用电感耦合等离子体质谱法测定长寿地区和非长寿地区老年人指甲中的元素谱，并利用正交投影到潜在结构判别分析（OPLS-DA）进行模式识别。结果，确定了与长寿地区健康老年人密切相关的四种特征元素，包括铬、铁、锰和钴。长寿地区组中铬、铁、锰和钴的浓度显著升高（p<0.05）。铬、铁、锰和钴的变化倍数分别为3.00、2.46、2.24和2.21。这些特征元素可为长寿地区老年人的健康和长寿提供重要的物质保障。进一步的相关性分析表明，老年人指甲中锶（r=0.886）、锰（r=0.873）、镍（r=0.786）和钴（r=0.738）的浓度与饮用水中的浓度呈显著正相关。此外，指甲中硒（r=0.940）、锰（r=0.833）和铁（r=0.733）的浓度与其膳食摄入量之间也存在显著正相关。因此，这些观察结果表明，饮食在反映来自长寿地区80岁以上健康老年人的元素谱特征方面可以提供特别的参考信息。
