左旋肉碱治疗对年龄相关性黄斑变性患者丙二醛和谷胱甘肽水平的影响。
The effect of L-carnitine treatment on levels of malondialdehyde and glutathione in patients with age related macular degeneration.
作者信息
Ates Orhan, Alp H Hakan, Mumcu Ugur, Azizi Sedat, Cinici Emine, Kiziltunc Ahmet, Baykal Orhan
机构信息
Atatürk University, Faculty of Medicine, Department of Ophtalmology, Erzurum, Turkey.
Atatürk University, Faculty of Medicine, Department of Biochemistry, Erzurum, Turkey.
出版信息
Eurasian J Med. 2008 Apr;40(1):1-5.
OBJECTIVE
The aim of this study was to determine the antioxidant properties of the L-carnitine (LC) in the treatment of patients with age-related macular degeneration (AMD).
MATERIALS AND METHODS
This study involved 60 patients diagnosed with early AMD. The patients were divided into two groups. Group I was the study group that received LC supplementation for 3 months. Group II was the control group and did not consent to LC supplementation over the 3 months. At the end of the 3-month period, markers of lipid peroxidation, malondialdehyde (MDA) and reduced glutathione (GSH) were measured in the two groups.
RESULTS
In the study group, the MDA level was significantly reduced, while the GSH level was significantly increased at the end of the 3-month period (P<0.001).
CONCLUSION
Our results suggest that LC may protect against oxidative damage by decreasing the MDA level, a marker of lipid peroxidation, and increasing GSH.
目的
本研究旨在确定左旋肉碱（LC）在治疗年龄相关性黄斑变性（AMD）患者中的抗氧化特性。
材料与方法
本研究纳入了60例被诊断为早期AMD的患者。患者被分为两组。第一组为研究组，接受LC补充剂治疗3个月。第二组为对照组，在3个月内不同意补充LC。在3个月疗程结束时，测量两组脂质过氧化标志物丙二醛（MDA）和还原型谷胱甘肽（GSH）。
结果
在研究组中，3个月末MDA水平显著降低，而GSH水平显著升高（P<0.001）。
结论
我们的结果表明，LC可能通过降低脂质过氧化标志物MDA水平和增加GSH来预防氧化损伤。
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