源自红树林产产黄青霉HDN11-24的青霉素醇A-C和青霉酸A
Penicitols A-C and penixanacid A from the mangrove-derived Penicillium chrysogenum HDN11-24.
作者信息
Guo Wenqiang, Li Dan, Peng Jixing, Zhu Tianjiao, Gu Qianqun, Li Dehai
机构信息
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
出版信息
J Nat Prod. 2015 Feb 27;78(2):306-10. doi: 10.1021/np500586r. Epub 2015 Jan 22.
Three new citrinin analogues, penicitols A-C (1-3), and one new xanthone derivative, penixanacid A (4), together with four known biogenetically related compounds (5-8), were discovered from the extract of a mangrove-derived fungus, Penicillium chrysogenum HND11-24. The structures of penicitols A-C and penixanacid A were established through analysis of extensive spectroscopic data. Their cytotoxic activity against HeLa, BEL-7402, HEK-293, HCT-116, and A549 cell lines was evaluated.
从一株源自红树林的产黄青霉HND11 - 24的提取物中发现了三种新的桔霉素类似物，青霉醇A - C（1 - 3），以及一种新的呫吨酮衍生物，青霉酸A（4），同时还发现了四种已知的生物合成相关化合物（5 - 8）。通过对大量光谱数据的分析确定了青霉醇A - C和青霉酸A的结构。评估了它们对HeLa、BEL - 7402、HEK - 293、HCT - 116和A549细胞系的细胞毒性活性。
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