从海洋来源真菌青霉 SCSGAF 0167 中分离得到的三个新的聚酮化合物。
Three new polyketides from marine-derived fungus Penicillium citrinum SCSGAF 0167.
机构信息
a Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, The Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301 , Guangdong , P.R. China.
出版信息
Nat Prod Res. 2014;28(4):239-44. doi: 10.1080/14786419.2013.843177. Epub 2013 Oct 4.
Three new polyketides penicitrinol G (1), penicitrinol H (2) and 2,11-dihydroxy-1-methoxycarbonyl-9-carboxylxanthone (3) together with one known cathepsin B inhibitor chrysophanol (4) were isolated from a culture broth of marine-derived fungus Penicillium citrinum SCSGAF 0167. Their structures were determined by spectroscopic methods. Compound 4 exhibited inhibitory activity against cathepsin B with IC50 value of 1.7 μM.
从海洋来源真菌青霉 SCSGAF 0167 的发酵液中分离得到三个新的聚酮化合物 penicitrinol G（1）、penicitrinol H（2）和 2,11-二羟基-1-甲氧羰基-9-羧基呫吨酮（3），以及一个已知的组织蛋白酶 B 抑制剂大黄素（4）。通过光谱方法确定了它们的结构。化合物 4 对组织蛋白酶 B 表现出抑制活性，IC50 值为 1.7 μM。
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