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Plakophilin 1 stimulates translation by promoting eIF4A1 activity.桥粒斑蛋白 1 通过促进 eIF4A1 活性来刺激翻译。
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Aberrant Expression Of PDCD4/eIF4A1 Signal Predicts Postoperative Recurrence For Early-Stage Oral Squamous Cell Carcinoma.PDCD4/eIF4A1信号异常表达可预测早期口腔鳞状细胞癌术后复发
Cancer Manag Res. 2019 Nov 11;11:9553-9562. doi: 10.2147/CMAR.S223273. eCollection 2019.
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Translation acrobatics: how cancer cells exploit alternate modes of translational initiation.翻译杂技：癌细胞如何利用翻译起始的替代模式。
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10
eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and Is Modulated by Phosphorylation.真核起始因子4A（eIF4A）RNA解旋酶在增殖细胞中与细胞周期蛋白依赖性蛋白激酶A相关，并受磷酸化调节。
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本文引用的文献

1
The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.乳腺癌中的恶性表型是由 eIF4A1 介导的翻译景观变化驱动的。
Cell Death Dis. 2015 Jan 22;6(1):e1603. doi: 10.1038/cddis.2014.542.
2
eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.eIF4F 是一种对 BRAF 和 MEK 抑制剂抗癌疗法产生抵抗的连接点。
Nature. 2014 Sep 4;513(7516):105-9. doi: 10.1038/nature13572. Epub 2014 Jul 27.
3
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.RNA G-四链体导致癌症中 eIF4A 依赖性癌基因翻译。
Nature. 2014 Sep 4;513(7516):65-70. doi: 10.1038/nature13485. Epub 2014 Jul 27.
4
A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma.真核起始因子 4B 过表达在弥漫性大 B 细胞淋巴瘤发病机制中的作用。
Leukemia. 2014 May;28(5):1092-102. doi: 10.1038/leu.2013.295. Epub 2013 Oct 18.
5
Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity.人类 eIF4E 通过刺激 eIF4A 解旋酶活性促进 mRNA 重排。
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13339-44. doi: 10.1073/pnas.1303781110. Epub 2013 Jul 30.
6
Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A.通过靶向抑制真核起始因子 4A 来改变化疗反应。
Blood Cancer J. 2013 Jul 19;3(7):e128. doi: 10.1038/bcj.2013.25.
7
The biological and therapeutic relevance of mRNA translation in cancer.mRNA 翻译在癌症中的生物学和治疗相关性。
Nat Rev Clin Oncol. 2011 May;8(5):280-91. doi: 10.1038/nrclinonc.2011.16. Epub 2011 Mar 1.
8
Dysregulation of protein synthesis and disease.蛋白质合成失调与疾病。
J Pathol. 2010 Jan;220(2):140-51. doi: 10.1002/path.2627.
9
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol.环戊并[b]苯并呋喃类化合物西维因的抗肿瘤活性及作用机制
PLoS One. 2009;4(4):e5223. doi: 10.1371/journal.pone.0005223. Epub 2009 Apr 29.
10
The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation.肿瘤抑制因子Pdcd4：功能与调控机制解析的最新进展
Biol Cell. 2009 Jun;101(6):309-17. doi: 10.1042/BC20080191.

eIF4A1 is a promising new therapeutic target in ER-negative breast cancer.

作者信息

Stoneley M, Willis A E

机构信息

MRC Toxicology Unit, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, UK.

出版信息

Cell Death Differ. 2015 Apr;22(4):524-5. doi: 10.1038/cdd.2014.210. Epub 2015 Jan 23.

DOI:10.1038/cdd.2014.210
PMID:25613380
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4356343/
Abstract
摘要