da Silva L C, Carrilho F J, da Fonseca L E, Faggion P, Arroyo S E, Tavares S M, Granato C F, Vianna M R, Alves V A, Gayotto L C
Rev Hosp Clin Fac Med Sao Paulo. 1989 Sep-Oct;44(5):193-6.
Few data on chronic hepatitis B (CHB) have been published in our country, despite the fact that it is responsible for more than 50% of all types of chronic hepatitis. From 1968 to 1988, 164 patients were attended with the diagnosis of CHB, from whom 136 (82.9%) were male. Only 11 (8.1%) admitted homosexual behavior. Twenty six out of 39 (66.7%) health professionals were medical doctors; among them 12 (46.2%) were surgeons. The mode of transmission was unknown in 55% of the cases, but vertical and sexual transmissions were also frequent. Commercial gammaglobulin, used with prophylactic purpose, was probably responsible for eight cases between 1972 and 1975. The most frequent forms of CH were chronic active hepatitis (CAH) and liver cirrhosis (LC): 72 or 43.9% and 53 or 32.3%, respectively. The predominance of HBeAg (66.4%) was observed in all forms of CHB. Repeated biopsies showed that chronic lobular hepatitis (CLH) and chronic persistent hepatitis (CPH) may occasionally progress to CAH. This form may persist as such for some years or progress to cirrhosis. In a few cases the evolution to CPH was observed. In the long term follow-up of our patients, the appearance of hepatocellular carcinoma was observed in 8 (4.9%).
尽管我国慢性乙型肝炎（CHB）导致的慢性肝炎占所有类型慢性肝炎的50%以上，但关于CHB的公开数据却很少。1968年至1988年期间，共诊治了164例CHB患者，其中136例（82.9%）为男性。只有11例（8.1%）承认有同性恋行为。39名卫生专业人员中有26名（66.7%）是医生；其中12名（46.2%）是外科医生。55%的病例传播途径不明，但垂直传播和性传播也很常见。1972年至1975年期间，8例病例可能是由于使用了用于预防目的的商业丙种球蛋白。CH最常见的形式是慢性活动性肝炎（CAH）和肝硬化（LC）：分别为72例（43.9%）和53例（32.3%）。在所有CHB形式中均观察到HBeAg占优势（66.4%）。重复活检显示，慢性小叶性肝炎（CLH）和慢性持续性肝炎（CPH）偶尔可能进展为CAH。这种形式可能会持续数年或进展为肝硬化。在少数病例中观察到了向CPH的演变。在对我们患者的长期随访中，8例（4.9%）出现了肝细胞癌。
