Portaleone D, Varenna R, Farolfi A, Ferrentino R, Di Leo M, Marcenaro R, Ranieri G, Rusinenti P, Seidita F, Signori S
Pediatr Med Chir. 1984 Sep-Oct;6(5):659-62.
Ten children with chronic hepatitis B have been followed for at least 3 years. All patients received 2 liver biopsies, the first after 1 year of continuous liver disfunction and HBsAg positivity, and the second 2 years after, that showed a mild improvement of the histologic lesions in 4 cases of chronic persistent hepatitis (CPH) and in 1 case of chronic lobular hepatitis (CLH). Three children out of 5 with chronic active hepatitis (CAN) changed to CPH and the other 2 remained unchanged without any evidence of cirrhosis. No patient received any drug for the treatment of hepatitis.
十名慢性乙型肝炎患儿已接受了至少3年的随访。所有患者均接受了两次肝活检，第一次在持续肝功能不全和HBsAg阳性1年后进行，第二次在2年后进行，结果显示4例慢性持续性肝炎（CPH）和1例慢性小叶性肝炎（CLH）的组织学病变有轻度改善。5例慢性活动性肝炎（CAN）患儿中有3例转变为CPH，另外2例保持不变，无任何肝硬化迹象。没有患者接受任何治疗肝炎的药物。
