Venter Carina, Sommer Isolde, Moonesinghe Harriet, Grundy Jane, Glasbey Gillian, Patil Veeresh, Dean Taraneh
School of Health Sciences and Social Work, University of Portsmouth, Portsmouth, UK; The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport, Isle of Wight, UK.
Pediatr Allergy Immunol. 2015 Mar;26(2):126-32. doi: 10.1111/pai.12337.
The few studies measuring health-related quality of life (HRQL) in food hypersensitivity (FHS) have found significantly reduced HRQL in patients and their families, particularly in the areas of family and social activities, emotional issues and family economy. One aspect that has not been studied is the effect of suspected FHS (food allergy/intolerance) vs. diagnosed FHS [based on a food challenge or a positive skin prick test (SPT) and good clinical history] on HRQL. Therefore, the aim of this study was to investigate the HRQL in children with a proven diagnosis of FHS vs. those with reported FHS.
We have utilized the 10-yr old follow-up cohort of the Food Allergy and Intolerance Research (FAIR) study from the Isle of Wight and assessed the child's HRQL with the Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) which measures HRQL using four domains: food anxiety, emotional impact, social and dietary limitation.
When comparing the two groups of children (proven FHS vs. perceived FHS), no difference in HRQL was found, although food anxiety showed a p-value of (p = 0.062). This was also the case when correcting for all confounding factors identified.
We have found that having a clear diagnosis of FHS is not an independent predictor of HRQL. Future studies are required comparing two more similar groups. We also need to focus more on the effect of continuous input from the multidisciplinary team on HRQL and which particular factors of FHS management affect HRQL.
少数针对食物过敏（FHS）患者健康相关生活质量（HRQL）的研究发现，患者及其家人的HRQL显著降低，尤其是在家庭和社交活动、情绪问题及家庭经济方面。尚未研究的一个方面是疑似FHS（食物过敏/不耐受）与已确诊的FHS（基于食物激发试验或阳性皮肤点刺试验（SPT）及良好的临床病史）对HRQL的影响。因此，本研究的目的是调查已确诊FHS的儿童与报告有FHS的儿童的HRQL。
我们利用了怀特岛食物过敏与不耐受研究（FAIR）的10年随访队列，并使用食物过敏生活质量问卷家长版（FAQLQ-PF）评估儿童的HRQL，该问卷通过食物焦虑、情绪影响、社交和饮食限制四个领域来衡量HRQL。
比较两组儿童（确诊FHS与疑似FHS）时，未发现HRQL有差异，尽管食物焦虑的p值为（p = 0.062）。在校正所有已识别的混杂因素后，情况也是如此。
我们发现，明确诊断FHS并非HRQL的独立预测因素。未来需要对两个更相似的组进行比较研究。我们还需要更多地关注多学科团队的持续投入对HRQL的影响以及FHS管理的哪些特定因素会影响HRQL。
