一项评估个性化瑜伽对接受强化化疗的住院儿童的可行性的试点研究。
A pilot study to evaluate the feasibility of individualized yoga for inpatient children receiving intensive chemotherapy.
作者信息
Diorio Caroline, Schechter Tal, Lee Michelle, O'Sullivan Cathy, Hesser Tanya, Tomlinson Deborah, Piscione Janine, Armstrong Christine, Tomlinson George, Sung Lillian
出版信息
BMC Complement Altern Med. 2015 Jan 24;15:2. doi: 10.1186/s12906-015-0529-3.
BACKGROUND
Fatigue is an important problem in paediatric cancer patients and yoga may be an effective intervention. The primary objective was to determine the feasibility of individualized yoga for hospitalized children receiving intensive chemotherapy.
METHODS
We included English-speaking children and adolescents aged 7-18 years receiving intensive chemotherapy or haematopoietic stem cell transplantation (HSCT). Yoga was conducted three times weekly for three weeks. The primary outcome was feasibility, defined as ability to deliver at least 60% of planned sessions. Secondary outcomes were parent-reported Pediatric Quality of Life Inventory (PedsQL) Multidimensional Fatigue Scale, Fatigue Scale-Parent, PedsQL Generic Core Scales and PedsQL Acute Cancer Module.
RESULTS
Between January and October 2013, 11 patients were enrolled. Median age was 14.0 (range 7.7-16.4) years and 6 (55%) were boys. Yoga was feasible with 10/11 participants meeting the threshold for feasibility. The median number of yoga sessions was 9 (range 3-13). No adverse events were attributed to yoga. Mean±standard deviation for the day 21 proxy-reported PedsQL general fatigue scores was 55.6±15.5. Qualitative comments suggested design changes for future yoga studies.
CONCLUSIONS
Individualized yoga is feasible for inpatient children receiving intensive chemotherapy. Future work will include development and conduct of a randomized trial for fatigue amelioration.
TRIAL REGISTRATION
ClinicalTrials.gov NCT02105389.
背景
疲劳是儿科癌症患者面临的一个重要问题，瑜伽可能是一种有效的干预措施。主要目的是确定为接受强化化疗的住院儿童提供个性化瑜伽的可行性。
方法
我们纳入了年龄在7 - 18岁、讲英语、接受强化化疗或造血干细胞移植（HSCT）的儿童和青少年。瑜伽每周进行三次，共持续三周。主要结局是可行性，定义为能够完成至少60%的计划课程。次要结局包括家长报告的儿童生活质量量表（PedsQL）多维疲劳量表、疲劳量表 - 家长版、PedsQL通用核心量表和PedsQL急性癌症模块。
结果
在2013年1月至10月期间，招募了11名患者。中位年龄为14.0岁（范围7.7 - 16.4岁），6名（55%）为男孩。10/11的参与者达到了可行性阈值，表明瑜伽是可行的。瑜伽课程的中位数为9节（范围3 - 13节）。没有不良事件归因于瑜伽。第21天代理报告的PedsQL一般疲劳评分的平均值±标准差为55.6±15.5。定性评论为未来的瑜伽研究提出了设计改进建议。
结论
为接受强化化疗的住院儿童提供个性化瑜伽是可行的。未来的工作将包括开展一项改善疲劳的随机试验。
试验注册
ClinicalTrials.gov NCT02105389。
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