Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
Environ Pollut. 2015 Apr;199:18-25. doi: 10.1016/j.envpol.2014.12.035. Epub 2015 Jan 21.
As a highly toxic heavy metal, the pollution and exposure risks of lead are of widespread concern for human health. However, the collection of blood samples for use as an indicator of lead pollution is not always feasible in most cohort or longitudinal studies, especially those involving children health. To evaluate the potential use of urinary lead as an indicator of exposure levels and source apportionment, accompanying with environmental media samples, lead concentrations and isotopic measurements (expressed as (207)Pb/(206)Pb, (208)Pb/(206)Pb and (204)Pb/(206)Pb) were investigated and compared between blood and urine from children living in the vicinities of a typical coking plant and lead-acid battery factory. The results showed urinary lead might not be a preferable proxy for estimating blood lead levels. Fortunately, urinary lead isotopic measurements could be used as an alternative for identifying the sources of children's lead exposure, which coincided well with the blood lead isotope ratio analysis.
作为一种剧毒重金属，铅的污染和暴露风险对人类健康普遍存在担忧。然而，在大多数队列或纵向研究中，尤其是涉及儿童健康的研究中，采集血样作为铅污染的指标并不总是可行的。为了评估尿铅作为暴露水平和来源分配的指标的潜力，同时采集环境介质样本，研究人员比较了居住在典型焦化厂和铅酸电池厂附近的儿童的血液和尿液中的铅浓度和同位素测量值（表示为(207)Pb/(206)Pb、(208)Pb/(206)Pb 和 (204)Pb/(206)Pb）。结果表明，尿铅可能不是估计血铅水平的理想替代物。幸运的是，尿铅同位素测量值可用作识别儿童铅暴露源的替代指标，这与血铅同位素比分析结果吻合较好。
