Miron Caitlin E, Petitjean Anne
Department of Chemistry, Queen's University, Chernoff Hall, 90 Bader Lane, Kingston ON K7L 3N6 (Canada).
Chembiochem. 2015 Feb 9;16(3):365-79. doi: 10.1002/cbic.201402549. Epub 2015 Jan 23.
At the cellular level, numerous processes ranging from protein folding to disease development are mediated by a sugar-based molecular information system that is much less well known than its DNA- or protein-based counterparts. The subtle structural diversity of such sugar tags nevertheless offers an excellent, if challenging, opportunity to design receptors for the selective recognition of biorelevant sugars. Over the past 40 years, growing interest in the field of sugar recognition has led to the development of several promising artificial receptors, which could soon find widespread use in medical diagnostics and cell imaging.
在细胞水平上，从蛋白质折叠到疾病发展的众多过程是由一个基于糖的分子信息系统介导的，该系统远不如基于DNA或蛋白质的对应系统那么为人所知。然而，这种糖标签微妙的结构多样性为设计用于选择性识别生物相关糖的受体提供了一个极好的机会，尽管颇具挑战性。在过去40年里，对糖识别领域日益增长的兴趣促使了几种有前景的人工受体的开发，这些受体可能很快在医学诊断和细胞成像中得到广泛应用。
