School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Chem Soc Rev. 2019 Nov 11;48(22):5488-5505. doi: 10.1039/c8cs00768c.
Glycans - simple or complex carbohydrates - play key roles as recognition determinants and modulators of numerous physiological and pathological processes. Thus, many biotechnological, diagnostic and therapeutic opportunities abound for molecular recognition entities that can bind glycans with high selectivity and affinity. This review begins with an overview of the current biologically and synthetically derived glycan-binding scaffolds that include antibodies, lectins, aptamers and boronic acid-based entities. It is followed by a more detailed discussion on various aspects of their generation, structure and recognition properties. It serves as the basis for highlighting recent key developments and technical challenges that must be overcome in order to fully deal with the specific recognition of a highly diverse and complex range of glycan structures.
糖链——简单或复杂的碳水化合物——在许多生理和病理过程中作为识别决定因素和调节剂发挥着关键作用。因此，许多生物技术、诊断和治疗机会都存在于能够与糖链高选择性和亲和力结合的分子识别实体中。这篇综述首先概述了当前具有生物和合成来源的糖结合支架，包括抗体、凝集素、适体和硼酸基实体。随后更详细地讨论了它们的生成、结构和识别特性的各个方面。它为突出最近的关键发展和技术挑战提供了基础，这些挑战必须克服，以便能够充分处理高度多样化和复杂的糖链结构的特定识别。
