Duan Hui-Feng, Gan Jing-Li, Yang Jia-Ming, Cheng Zheng-Xiang, Gao Cun-You, Shi Zhen-Juan, Zhu Xi-Quan, Liang Xue-Jun, Zhao Lan-Min
Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, PLA 91st Central Hospital, Jiaozuo 454003, Henan Province, PR China.
Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, PLA 91st Central Hospital, Jiaozuo 454003, Henan Province, PR China.
Behav Brain Res. 2015 Apr 15;283:78-86. doi: 10.1016/j.bbr.2015.01.022. Epub 2015 Jan 22.
Hippocampal pathology has been considered to underlie clinical, functional and cognitive impairments in schizophrenia. While longitudinal magnetic resonance imaging (MRI) studies have demonstrated progressive gray matter reduction of the hippocampus during the early phases of schizophrenia (SCZ), very little is known about whether functional connectivity (FC) between the hippocampus and other brain regions also exhibit progressive changes. In this study, resting state functional MRI (fMRI) was used to examine changes in hippocampal connectivity at baseline and follow-up scans comparing 68 patients with first episode SCZ and 62 matched controls. At baseline and follow-up, in the bilateral hippocampal network, SCZ mainly showed decreased FC with bilateral cerebellum posterior lobe, frontal gyrus temporal gyrus, precuneus, and cingulate cortex compared to controls. Furthermore, in the bilateral hippocampus, there was a significant interaction effect of group and time for FC with cerebellum posterior lobe, temporal gyrus, frontal gyrus, and posterior cingulate cortex. Interestingly, longitudinal changes of bilateral hippocampal connectivity with right middle frontal gyrus negatively correlated with positive symptom scores in SCZ. These results provide novel evidence for the progressive changes of FC between hippocampus and other brain regions in SCZ. It further suggests that longitudinal changes of bilateral hippocampal connectivity with right middle frontal gyrus can contribute to the formation and emergence of positive symptom of SCZ.
海马体病理被认为是精神分裂症临床、功能和认知障碍的基础。虽然纵向磁共振成像（MRI）研究表明，在精神分裂症（SCZ）早期，海马体灰质会逐渐减少，但对于海马体与其他脑区之间的功能连接（FC）是否也会出现渐进性变化，我们知之甚少。在这项研究中，静息态功能MRI（fMRI）被用于检查68例首发SCZ患者和62例匹配对照在基线和随访扫描时海马体连接性的变化。在基线和随访时，在双侧海马体网络中，与对照组相比，SCZ主要表现为与双侧小脑后叶、额回、颞回、楔前叶和扣带回皮质的FC降低。此外，在双侧海马体中，与小脑后叶、颞回、额回和后扣带回皮质的FC存在显著的组间和时间交互作用。有趣的是，双侧海马体与右侧额中回连接性的纵向变化与SCZ的阳性症状评分呈负相关。这些结果为SCZ中海马体与其他脑区之间FC的渐进性变化提供了新证据。这进一步表明，双侧海马体与右侧额中回连接性的纵向变化可能有助于SCZ阳性症状的形成和出现。
