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目前的脑出血动物模型是否反映了人类的病理学?

Do current animal models of intracerebral hemorrhage mirror the human pathology?

机构信息

Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA,

出版信息

Transl Stroke Res. 2011 Mar;2(1):17-25. doi: 10.1007/s12975-010-0037-1. Epub 2010 Aug 10.

DOI:10.1007/s12975-010-0037-1
PMID:24323583
Abstract

Although intracerebral hemorrhage (ICH) has no proven treatment, well-designed studies using animal models of ICH may lead to the development of novel therapies. We briefly review current animal models of ICH. Furthermore, we discuss how these models may be utilized and targeted to facilitate translation of preclinical findings to the clinical arena.

摘要

虽然脑出血(ICH)尚无有效的治疗方法,但使用 ICH 动物模型进行精心设计的研究可能会为新疗法的开发提供依据。我们简要回顾了当前的 ICH 动物模型。此外,我们还讨论了如何利用和针对这些模型,以促进将临床前研究结果转化为临床应用。

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1
Do current animal models of intracerebral hemorrhage mirror the human pathology?目前的脑出血动物模型是否反映了人类的病理学?
Transl Stroke Res. 2011 Mar;2(1):17-25. doi: 10.1007/s12975-010-0037-1. Epub 2010 Aug 10.
2
Comparison of different preclinical models of intracerebral hemorrhage.不同脑出血临床前模型的比较
Acta Neurochir Suppl. 2011;111:9-14. doi: 10.1007/978-3-7091-0693-8_2.
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Stem cell therapy in intracerebral hemorrhage rat model.脑出血大鼠模型中的干细胞治疗
World J Stem Cells. 2015 Apr 26;7(3):618-29. doi: 10.4252/wjsc.v7.i3.618.
4
Preclinical models of intracerebral hemorrhage: a translational perspective.脑出血的临床前模型:转化医学视角
Neurocrit Care. 2008;9(1):139-52. doi: 10.1007/s12028-007-9030-2.
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Programmed Cell Death after Intracerebral Hemorrhage.脑出血后的细胞程序性死亡。
Curr Neuropharmacol. 2018;16(9):1267-1281. doi: 10.2174/1570159X15666170602112851.
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Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update.脑出血相关炎症的潜在治疗靶点:最新进展。
J Cereb Blood Flow Metab. 2020 Sep;40(9):1752-1768. doi: 10.1177/0271678X20923551. Epub 2020 May 19.
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Biological Effects of Hydrogen Sulfide and Its Protective Role in Intracerebral Hemorrhage.硫化氢的生物学效应及其在脑出血中的保护作用。
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Therapeutic Potential of Drugs Targeting Pathophysiology of Intracerebral Hemorrhage: From Animal Models to Clinical Applications.针对脑出血病理生理学的药物治疗潜力:从动物模型到临床应用
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Priorities for clinical research in intracerebral hemorrhage: report from a National Institute of Neurological Disorders and Stroke workshop.脑出血临床研究的优先事项:美国国立神经疾病与中风研究所研讨会报告
Stroke. 2005 Mar;36(3):e23-41. doi: 10.1161/01.STR.0000155685.77775.4c. Epub 2005 Feb 3.
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New horizons for primary intracerebral hemorrhage treatment: experience from preclinical studies.原发性脑出血治疗的新视野:来自临床前研究的经验
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Monitoring neonatal brain hemorrhage progression by photoacoustic tomography.通过光声断层扫描监测新生儿脑出血进展。
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miR-181a Mediates Inflammatory Gene Expression After Intracerebral Hemorrhage: An Integrated Analysis of miRNA-seq and mRNA-seq in a Swine ICH Model.miR-181a 在脑出血后介导炎症基因表达:猪脑出血模型中 miRNA-seq 和 mRNA-seq 的综合分析。
J Mol Neurosci. 2021 Sep;71(9):1802-1814. doi: 10.1007/s12031-021-01815-9. Epub 2021 Mar 23.
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本文引用的文献

1
Deferoxamine treatment for intracerebral hemorrhage in aged rats: therapeutic time window and optimal duration.去铁胺治疗老年大鼠脑出血:治疗时间窗和最佳持续时间。
Stroke. 2010 Feb;41(2):375-82. doi: 10.1161/STROKEAHA.109.569830. Epub 2009 Dec 31.
2
Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice.急性和慢性高血压小鼠的自发性脑出血。
J Cereb Blood Flow Metab. 2010 Jan;30(1):56-69. doi: 10.1038/jcbfm.2009.183. Epub 2009 Sep 2.
3
Aging exacerbates intracerebral hemorrhage-induced brain injury.
脑出血转化研究:当前神经保护研究的实验设计和报告标准是否已经达到?
Transl Stroke Res. 2020 Dec;11(6):1203-1213. doi: 10.1007/s12975-020-00824-x. Epub 2020 Jun 5.
4
Optimized lactoferrin as a highly promising treatment for intracerebral hemorrhage: Pre-clinical experience.优化乳铁蛋白作为脑出血治疗的一种很有前景的方法:临床前经验。
J Cereb Blood Flow Metab. 2021 Jan;41(1):53-66. doi: 10.1177/0271678X20925667. Epub 2020 May 21.
5
Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat.多聚精氨酸-18 肽不会加重胶原酶诱导的大鼠脑出血后的出血,也不会改善功能结局。
PLoS One. 2019 Nov 7;14(11):e0224870. doi: 10.1371/journal.pone.0224870. eCollection 2019.
6
Intracerebral hemorrhage induces monocyte-related gene expression within six hours: Global transcriptional profiling in swine ICH.脑出血在 6 小时内诱导单核细胞相关基因表达:猪脑出血的全基因组转录谱分析。
Metab Brain Dis. 2019 Jun;34(3):763-774. doi: 10.1007/s11011-019-00399-z. Epub 2019 Feb 22.
7
Sonothrombolysis.超声溶栓
Adv Exp Med Biol. 2016;880:339-62. doi: 10.1007/978-3-319-22536-4_19.
8
Neonatal brain hemorrhage (NBH) of prematurity: translational mechanisms of the vascular-neural network.早产新生儿脑内出血:血管 - 神经网络的转化机制
Curr Med Chem. 2015;22(10):1214-38. doi: 10.2174/0929867322666150114152421.
9
Seizure activity occurs in the collagenase but not the blood infusion model of striatal hemorrhagic stroke in rats.癫痫活动发生在大鼠纹状体出血性中风的胶原酶模型中,而不是血液注入模型中。
Transl Stroke Res. 2015 Feb;6(1):29-38. doi: 10.1007/s12975-014-0361-y. Epub 2014 Jul 24.
10
Mechanisms of hydrocephalus after neonatal and adult intraventricular hemorrhage.新生儿和成人脑室出血后脑积水的发病机制。
Transl Stroke Res. 2012 Jul;3(Suppl 1):25-38. doi: 10.1007/s12975-012-0182-9.
衰老会加剧脑出血所致的脑损伤。
J Neurotrauma. 2009 Sep;26(9):1567-76. doi: 10.1089/neu.2008.0630.
4
Assessing functional outcomes following intracerebral hemorrhage in rats.评估大鼠脑出血后的功能结局。
Brain Res. 2009 Jul 14;1280:148-57. doi: 10.1016/j.brainres.2009.05.038. Epub 2009 May 21.
5
Intracerebral haemorrhage.脑出血
Lancet. 2009 May 9;373(9675):1632-44. doi: 10.1016/S0140-6736(09)60371-8.
6
Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage.在华法林相关脑出血小鼠模型中,快速逆转抗凝可减少出血量。
J Cereb Blood Flow Metab. 2009 May;29(5):1015-21. doi: 10.1038/jcbfm.2009.27. Epub 2009 Mar 25.
7
Transient focal increase in perihematomal glucose metabolism after acute human intracerebral hemorrhage.急性人类脑出血后血肿周围葡萄糖代谢的短暂性局灶性增加。
Stroke. 2009 May;40(5):1638-43. doi: 10.1161/STROKEAHA.108.536037. Epub 2009 Mar 12.
8
Update of the stroke therapy academic industry roundtable preclinical recommendations.中风治疗学术产业圆桌会议临床前建议更新
Stroke. 2009 Jun;40(6):2244-50. doi: 10.1161/STROKEAHA.108.541128. Epub 2009 Feb 26.
9
Depressed mood after intracerebral hemorrhage: the FAST trial.脑出血后情绪低落:FAST试验
Cerebrovasc Dis. 2009;27(4):353-60. doi: 10.1159/000202012. Epub 2009 Feb 14.
10
The future of restorative neurosciences in stroke: driving the translational research pipeline from basic science to rehabilitation of people after stroke.中风后修复性神经科学的未来:推动从基础科学到中风后患者康复的转化研究进程。
Neurorehabil Neural Repair. 2009 Feb;23(2):97-107. doi: 10.1177/1545968308326636.