Rumianowski B, Rotter I, Brodowska A, Adler G, Kowalski J, Karakiewicz B, Laszczyńska M
4. Department of Histology and Development Biology, Pomeranian Medical University, Szczecin, Poland.
Department of Medical Rehabilitation, Pomeranian Medical University, Szczecin, Poland.
Gesundheitswesen. 2016 Nov;78(11):749-751. doi: 10.1055/s-0034-1396847. Epub 2015 Jan 26.
Early menopause may be associated with serious health risks resulting from, for example, decreased oestrogen levels. This may occur despite hormone replacement therapy. The aim of this study was the determination of the effect of selected reproductive factors and smoking on age at the onset of menopause in women from Szczecin and surrounding areas. 305 women after natural menopause were asked to complete a questionnaire, and blood samples were collected from them to test for the levels of follicle stimulating hormone (FSH) and oestradiol (E2). Smoking women experienced menopause on average more than a year earlier than non-smokers, but this difference was not statistically significant. There was no statistically significant effect of age at menarche or first birth on age at the last menstrual period. Age at menarche and first birth were not related to age at menopause. In smoking women, menopause occurred earlier but the difference was not statistically significant.
过早绝经可能与严重的健康风险相关，例如雌激素水平降低。即便进行激素替代疗法，这种情况仍可能发生。本研究的目的是确定特定生殖因素和吸烟对什切青及周边地区女性绝经起始年龄的影响。305名自然绝经后的女性被要求填写一份问卷，并采集她们的血样以检测促卵泡激素（FSH）和雌二醇（E2）水平。吸烟女性绝经的平均年龄比不吸烟女性早一年多，但这种差异无统计学意义。初潮年龄或首次生育年龄对末次月经年龄没有统计学上的显著影响。初潮年龄和首次生育年龄与绝经年龄无关。在吸烟女性中，绝经发生得更早，但差异无统计学意义。
