羟嗪引起的QT间期延长：一份药物警戒病例报告。 - Suppr

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超能文献

QT prolongation induced by hydroxyzine: a pharmacovigilance case report.

作者信息

Vigne Jonathan, Alexandre Joachim, Fobe Fabienne, Milliez Paul, Loilier Magalie, Fedrizzi Sophie, Coquerel Antoine

机构信息

Department of Pharmacology and Pharmacovigilance, CHU de Caen, Caen, 14032, France.

出版信息

Eur J Clin Pharmacol. 2015 Mar;71(3):379-81. doi: 10.1007/s00228-014-1804-9. Epub 2015 Jan 28.

DOI:10.1007/s00228-014-1804-9

PMID:25622983

Abstract

摘要

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本文引用的文献

Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration.羟嗪（一种组胺 H（1）受体拮抗剂）对 hERG K（+）通道和心脏动作电位时程的影响。

Acta Pharmacol Sin. 2011 Sep;32(9):1128-37. doi: 10.1038/aps.2011.66.

Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation.羟嗪，一种第一代H(1)受体拮抗剂，抑制人醚-去极化相关基因（HERG）电流，并在一名患有HERG突变的患者中导致晕厥。

J Pharmacol Sci. 2008 Dec;108(4):462-71. doi: 10.1254/jphs.08178fp. Epub 2008 Dec 5.

Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study.左西替利嗪在健康受试者中不会延长QT/QTc间期：一项全面QT研究的结果。

Eur J Clin Pharmacol. 2007 Nov;63(11):1011-7. doi: 10.1007/s00228-007-0366-5. Epub 2007 Sep 21.

A simple high-performance liquid chromatographic method for detection of hydroxyzine in human plasma after overdose.一种用于检测过量用药后人血浆中羟嗪的简单高效液相色谱法。

J Pharmacol Toxicol Methods. 2004 Jul-Aug;50(1):41-4. doi: 10.1016/j.vascn.2004.01.001.

Risk of torsades de pointes with non-cardiac drugs. Doctors need to be aware that many drugs can cause qt prolongation.非心脏药物致尖端扭转型室性心动过速的风险。医生需要意识到许多药物可导致QT间期延长。

BMJ. 2000 Apr 29;320(7243):1158-9. doi: 10.1136/bmj.320.7243.1158.

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