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QT prolongation induced by hydroxyzine: a pharmacovigilance case report.

作者信息

Vigne Jonathan, Alexandre Joachim, Fobe Fabienne, Milliez Paul, Loilier Magalie, Fedrizzi Sophie, Coquerel Antoine

机构信息

Department of Pharmacology and Pharmacovigilance, CHU de Caen, Caen, 14032, France.

出版信息

Eur J Clin Pharmacol. 2015 Mar;71(3):379-81. doi: 10.1007/s00228-014-1804-9. Epub 2015 Jan 28.

DOI:10.1007/s00228-014-1804-9
PMID:25622983
Abstract
摘要

相似文献

1
QT prolongation induced by hydroxyzine: a pharmacovigilance case report.羟嗪引起的QT间期延长:一份药物警戒病例报告。
Eur J Clin Pharmacol. 2015 Mar;71(3):379-81. doi: 10.1007/s00228-014-1804-9. Epub 2015 Jan 28.
2
Hydroxyzine and QTc interval: drugs without sin cast the first stone!羟嗪与QTc间期:无罪的药物却首当其冲!
Minerva Anestesiol. 2016 Feb;82(2):240-1. Epub 2015 Sep 16.
3
The conventional antihistamine drug cyproheptadine lacks QT-interval-prolonging action in halothane-anesthetized guinea pigs: comparison with hydroxyzine.常规抗组胺药赛庚啶在氟烷麻醉豚鼠中缺乏 QT 间期延长作用:与羟嗪的比较。
J Pharmacol Sci. 2014;124(1):92-8. doi: 10.1254/jphs.13159fp. Epub 2013 Dec 27.
4
Neonatal seizures associated with maternal hydroxyzine hydrochloride in late pregnancy.
Reprod Toxicol. 2005 Nov-Dec;20(4):573-4. doi: 10.1016/j.reprotox.2005.03.005. Epub 2005 Apr 15.
5
Hydroxyzine: choose other treatments.羟嗪:选择其他治疗方法。
Prescrire Int. 2015 Jul;24(162):191.
6
Drug-induced QT prolongation.药物性QT间期延长
Isr Med Assoc J. 2000 Dec;2(12):924-8.
7
Exudative erythema multiforme induced by hydroxyzine.由羟嗪引起的渗出性多形红斑。
Eur J Dermatol. 2008 Mar-Apr;18(2):194-5. doi: 10.1684/ejd.2008.0365.
8
Hydroxyzine-induced Vertical Nystagmus.羟嗪诱发的垂直性眼球震颤。
Indian Pediatr. 2018 Dec 15;55(12):1094.
9
Skin reaction to hydroxyzine (Atarax): patch test utility.
Contact Dermatitis. 2006 Apr;54(4):216-7. doi: 10.1111/j.0105-1873.2006.0775d.x.
10
[A case of catatonia associated with the ingestion of hydroxyzine].[一例与服用羟嗪相关的紧张症病例]
No To Shinkei. 2005 Jan;57(1):45-9.

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Predicting the toxic side effects of drug interactions using chemical structures and protein sequences.利用化学结构和蛋白质序列预测药物相互作用的毒副作用。
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Association between First-Generation Antihistamine Use in Children and Cardiac Arrhythmia and Ischemic Heart Disease: A Case-Crossover Study.儿童使用第一代抗组胺药与心律失常和缺血性心脏病之间的关联:一项病例交叉研究。
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本文引用的文献

1
Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration.羟嗪(一种组胺 H(1)受体拮抗剂)对 hERG K(+)通道和心脏动作电位时程的影响。
Acta Pharmacol Sin. 2011 Sep;32(9):1128-37. doi: 10.1038/aps.2011.66.
2
Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation.羟嗪,一种第一代H(1)受体拮抗剂,抑制人醚-去极化相关基因(HERG)电流,并在一名患有HERG突变的患者中导致晕厥。
J Pharmacol Sci. 2008 Dec;108(4):462-71. doi: 10.1254/jphs.08178fp. Epub 2008 Dec 5.
3
迈向过敏性鼻炎的确定性管理:新型和现有疗法的最佳应用
Allergy Asthma Clin Immunol. 2020 May 27;16:39. doi: 10.1186/s13223-020-00436-y. eCollection 2020.
4
Measurement and Management of QT Interval Prolongation for General Physicians.一般内科医师的 QT 间期延长的测量与管理。
J Gen Intern Med. 2020 Mar;35(3):865-873. doi: 10.1007/s11606-019-05477-7. Epub 2019 Oct 25.
5
CSACI position statement: Newer generation H-antihistamines are safer than first-generation H-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria.加拿大过敏、哮喘和免疫学会立场声明:新一代H-抗组胺药比第一代H-抗组胺药更安全,应作为治疗过敏性鼻炎和荨麻疹的一线抗组胺药。
Allergy Asthma Clin Immunol. 2019 Oct 1;15:61. doi: 10.1186/s13223-019-0375-9. eCollection 2019.
6
Use of antihistamines and risk of ventricular tachyarrhythmia: a nested case-control study in five European countries from the ARITMO project.抗组胺药的使用与室性快速性心律失常风险:来自ARITMO项目的五个欧洲国家的巢式病例对照研究。
Eur J Clin Pharmacol. 2017 Nov;73(11):1499-1510. doi: 10.1007/s00228-017-2317-0. Epub 2017 Aug 22.
7
Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re-evaluation of an established drug.与服用羟嗪相关的QT间期延长和尖端扭转型室性心动过速风险:对一种已上市药物的重新评估。
Pharmacol Res Perspect. 2017 Apr 21;5(3):e00309. doi: 10.1002/prp2.309. eCollection 2017 Jun.
Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study.
左西替利嗪在健康受试者中不会延长QT/QTc间期:一项全面QT研究的结果。
Eur J Clin Pharmacol. 2007 Nov;63(11):1011-7. doi: 10.1007/s00228-007-0366-5. Epub 2007 Sep 21.
4
A simple high-performance liquid chromatographic method for detection of hydroxyzine in human plasma after overdose.一种用于检测过量用药后人血浆中羟嗪的简单高效液相色谱法。
J Pharmacol Toxicol Methods. 2004 Jul-Aug;50(1):41-4. doi: 10.1016/j.vascn.2004.01.001.
5
Risk of torsades de pointes with non-cardiac drugs. Doctors need to be aware that many drugs can cause qt prolongation.非心脏药物致尖端扭转型室性心动过速的风险。医生需要意识到许多药物可导致QT间期延长。
BMJ. 2000 Apr 29;320(7243):1158-9. doi: 10.1136/bmj.320.7243.1158.