利用雅致小克银汉霉从10,11-二甲氧基阿朴啡进行异阿朴可待因的区域特异性合成。
Regiospecific synthesis of isoapocodeine from 10,11-dimethoxyaporphine by using Cunninghamella elegans.
作者信息
Smith R V, Davis P J
出版信息
Appl Environ Microbiol. 1978 Apr;35(4):738-42. doi: 10.1128/aem.35.4.738-742.1978.
Abstract
A preparative-scale regiospecific conversion of 10,11-dimethoxyaporphine to isoapocodeine was conducted with Cunninghamella elegans ATCC 9245. This biotransformation proceeded quantitatively in suspensions and was pH dependent. The influence of antioxidants on the conversion was studied. Attempts to preserve the activity of isolated C. elegans cells by a number of methods were unsuccessful.
摘要
利用雅致小克银汉霉ATCC 9245进行了从10,11 - 二甲氧基阿朴啡到异阿朴可待因的制备规模区域特异性转化。这种生物转化在悬浮液中定量进行，且依赖于pH值。研究了抗氧化剂对该转化的影响。尝试通过多种方法保存分离的雅致小克银汉霉细胞的活性，但均未成功。
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