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Regiospecific synthesis of isoapocodeine from 10,11-dimethoxyaporphine by using Cunninghamella elegans.利用雅致小克银汉霉从10,11-二甲氧基阿朴啡进行异阿朴可待因的区域特异性合成。
Appl Environ Microbiol. 1978 Apr;35(4):738-42. doi: 10.1128/aem.35.4.738-742.1978.
2
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本文引用的文献

1
Apomorphine HCL stabilization.盐酸阿扑吗啡的稳定性
J Am Pharm Assoc. 1968 Apr;8(4):198-9. doi: 10.1016/s0003-0465(16)30568-7.
2
Induction and inhibition of in vivo glucuronidation of apomorphine in mice.小鼠体内阿扑吗啡葡萄糖醛酸化的诱导与抑制
J Pharm Sci. 1971 Jan;60(1):93-5. doi: 10.1002/jps.2600600118.
3
Microbiological synthesis of L-3,4-dihydroxyphenylalanine.
J Am Chem Soc. 1969 Oct 22;91(22):6204. doi: 10.1021/ja01050a061.
4
Centrally acting emetics. 5. Preparation and pharmacology of 10-hydroxy-11 methoxyaporphine (isoapocodeine). In vitro enzymatic methylation of apomorphine.中枢性催吐药。5. 10-羟基-11-甲氧基阿朴啡（异阿朴可待因）的制备与药理学。阿朴吗啡的体外酶促甲基化。
J Med Chem. 1972 Mar;15(3):273-6. doi: 10.1021/jm00273a016.
5
Pilot plant conversion of steroid using resting cell suspension as biocatalyst.以静止细胞悬浮液作为生物催化剂对类固醇进行中试工厂转化。
Biotechnol Bioeng. 1972 Sep;14(5):831-41. doi: 10.1002/bit.260140512.
6
Microbial models of mammalian metabolism. Aromatic hydroxylation.
Arch Biochem Biophys. 1974 Apr 2;161(2):551-8. doi: 10.1016/0003-9861(74)90338-5.
7
Microbial models of mammalian metabolism.
J Pharm Sci. 1975 Nov;64(11):1737-59. doi: 10.1002/jps.2600641104.
8
Microbial models of mammalian metabolism. O-Dealkylation of 10,11-dimethoxyaporphine.哺乳动物新陈代谢的微生物模型。10,11-二甲氧基阿朴啡的O-脱烷基化反应
J Med Chem. 1975 Aug;18(8):791-4. doi: 10.1021/jm00242a006.
9
Treatment of Parkinson's disease with aporphines. Possible role of growth hormone.阿朴啡类药物治疗帕金森病。生长激素的可能作用。
N Engl J Med. 1976 Mar 11;294(11):567-72. doi: 10.1056/NEJM197603112941101.
10
Prolonged apomorphine-like behavioural effects of apomorphine esters.阿扑吗啡酯类药物具有类似阿扑吗啡的长期行为效应。
Neuropharmacology. 1976 Aug;15(8):471-8. doi: 10.1016/0028-3908(76)90057-5.

利用雅致小克银汉霉从10,11-二甲氧基阿朴啡进行异阿朴可待因的区域特异性合成。

Regiospecific synthesis of isoapocodeine from 10,11-dimethoxyaporphine by using Cunninghamella elegans.

作者信息

Smith R V, Davis P J

出版信息

Appl Environ Microbiol. 1978 Apr;35(4):738-42. doi: 10.1128/aem.35.4.738-742.1978.

DOI:10.1128/aem.35.4.738-742.1978
PMID:25623
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC242915/
Abstract

A preparative-scale regiospecific conversion of 10,11-dimethoxyaporphine to isoapocodeine was conducted with Cunninghamella elegans ATCC 9245. This biotransformation proceeded quantitatively in suspensions and was pH dependent. The influence of antioxidants on the conversion was studied. Attempts to preserve the activity of isolated C. elegans cells by a number of methods were unsuccessful.

摘要

利用雅致小克银汉霉ATCC 9245进行了从10,11 - 二甲氧基阿朴啡到异阿朴可待因的制备规模区域特异性转化。这种生物转化在悬浮液中定量进行，且依赖于pH值。研究了抗氧化剂对该转化的影响。尝试通过多种方法保存分离的雅致小克银汉霉细胞的活性，但均未成功。