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本文引用的文献

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Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : III. Zygotic loci on the X-chromosome and fourth chromosome.影响黑腹果蝇幼虫表皮模式的突变:III. X染色体和第四条染色体上的合子基因座
Wilehm Roux Arch Dev Biol. 1984 Sep;193(5):296-307. doi: 10.1007/BF00848158.
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Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : II. Zygotic loci on the third chromosome.影响黑腹果蝇幼虫表皮模式的突变:II. 第三条染色体上的合子基因座
Wilehm Roux Arch Dev Biol. 1984 Sep;193(5):283-295. doi: 10.1007/BF00848157.
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Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : I. Zygotic loci on the second chromosome.影响黑腹果蝇幼虫表皮模式的突变:I. 第二条染色体上的合子基因座。
Wilehm Roux Arch Dev Biol. 1984 Sep;193(5):267-282. doi: 10.1007/BF00848156.
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FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations.果蝇数据库:黑腹果蝇6.0版本参考基因组组装的介绍及基因组注释的大规模迁移
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A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases.用于研究人类遗传疾病潜在机制的果蝇突变体遗传资源。
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Large-scale identification of chemically induced mutations in Drosophila melanogaster.黑腹果蝇化学诱导突变的大规模鉴定。
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Wisdom from the fly.苍蝇的智慧。
Trends Genet. 2014 Nov;30(11):479-81. doi: 10.1016/j.tig.2014.08.003. Epub 2014 Aug 24.
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A transposable element insertion confers xenobiotic resistance in Drosophila.转座因子插入赋予果蝇对外源生物的抗性。
PLoS Genet. 2014 Aug 14;10(8):e1004560. doi: 10.1371/journal.pgen.1004560. eCollection 2014 Aug.
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Human dominant disease genes are enriched in paralogs originating from whole genome duplication.人类显性疾病基因在源自全基因组复制的旁系同源基因中富集。
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生物医学研究中的果蝇。

Fruit flies in biomedical research.

作者信息

Wangler Michael F, Yamamoto Shinya, Bellen Hugo J

机构信息

Department of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, Texas 77030 Department of Pediatrics, Baylor College of Medicine (BCM), Houston, Texas 77030 Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030.

Department of Molecular and Human Genetics, Baylor College of Medicine (BCM), Houston, Texas 77030 Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas 77030 Program in Developmental Biology, Baylor College of Medicine (BCM), Texas 77030.

出版信息

Genetics. 2015 Mar;199(3):639-53. doi: 10.1534/genetics.114.171785. Epub 2015 Jan 26.

DOI:10.1534/genetics.114.171785
PMID:25624315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4349060/
Abstract

Many scientists complain that the current funding situation is dire. Indeed, there has been an overall decline in support in funding for research from the National Institutes of Health and the National Science Foundation. Within the Drosophila field, some of us question how long this funding crunch will last as it demotivates principal investigators and perhaps more importantly affects the long-term career choice of many young scientists. Yet numerous very interesting biological processes and avenues remain to be investigated in Drosophila, and probing questions can be answered fast and efficiently in flies to reveal new biological phenomena. Moreover, Drosophila is an excellent model organism for studies that have translational impact for genetic disease and for other medical implications such as vector-borne illnesses. We would like to promote a better collaboration between Drosophila geneticists/biologists and human geneticists/bioinformaticians/clinicians, as it would benefit both fields and significantly impact the research on human diseases.

摘要

许多科学家抱怨当前的资金状况严峻。的确,美国国立卫生研究院和美国国家科学基金会对研究的资金支持总体上有所下降。在果蝇研究领域,我们中的一些人质疑这种资金短缺将持续多久,因为它会打击首席研究员的积极性,也许更重要的是会影响许多年轻科学家的长期职业选择。然而,果蝇中仍有许多非常有趣的生物学过程和研究方向有待探索,而且在果蝇中可以快速有效地回答探究性问题,以揭示新的生物学现象。此外,果蝇是一种出色的模式生物,适用于对遗传疾病以及其他医学问题(如病媒传播疾病)具有转化影响的研究。我们希望促进果蝇遗传学家/生物学家与人类遗传学家/生物信息学家/临床医生之间更好的合作,因为这将使两个领域都受益,并对人类疾病的研究产生重大影响。