Kang Hyun-Mi, Lee Eun-Kyoung, Song Byung-Min, Jeong Jipseol, Choi Jun-Gu, Jeong Joojin, Moon Oun-Kyong, Yoon Hachung, Cho Youngmi, Kang Young-Myong, Lee Hee-Soo, Lee Youn-Jeong
Emerg Infect Dis. 2015 Feb;21(2):298-304. doi: 10.3201/eid2102.141268.
An outbreak of highly pathogenic avian influenza, caused by a novel reassortant influenza A (H5N8) virus, occurred among poultry and wild birds in South Korea in 2014. The aim of this study was to evaluate the pathogenesis in and mode of transmission of this virus among domestic and wild ducks. Three of the viruses had similar pathogenicity among infected domestic ducks: the H5N8 viruses were moderately pathogenic (0%-20% mortality rate); in wild mallard ducks, the H5N8 and H5N1 viruses did not cause severe illness or death; viral replication and shedding were greater in H5N8-infected mallards than in H5N1-infected mallards. Identification of H5N8 viruses in birds exposed to infected domestic ducks and mallards indicated that the viruses could spread by contact. We propose active surveillance to support prevention of the spread of this virus among wild birds and poultry, especially domestic ducks.
2014年，韩国家禽和野鸟中爆发了由新型重组甲型流感病毒（H5N8）引起的高致病性禽流感。本研究的目的是评估该病毒在家鸭和野鸭中的发病机制及传播方式。三种病毒在感染的家鸭中致病性相似：H5N8病毒为中等致病性（死亡率0%-20%）；在野鸭中，H5N8和H5N1病毒未引起严重疾病或死亡；H5N8感染的野鸭中病毒复制和排毒量高于H5N1感染的野鸭。在接触感染家鸭和野鸭的鸟类中检测到H5N8病毒，表明该病毒可通过接触传播。我们建议进行主动监测，以支持预防该病毒在野鸟和家禽，尤其是家鸭之间的传播。
