Reddy Murali Mohan, Dhas Devavaram Jackson, Dhas Jebasingh, Adeghate Ernest, Starling Emerald Bright
Department of Pharmacology, Mohamed Sathak A.J. College of Pharmacy , Chennai, Tamil Nadu , India .
Pharm Biol. 2015 Aug;53(8):1133-40. doi: 10.3109/13880209.2014.962058. Epub 2015 Jan 27.
Hyperlipidemia is known to be a major risk factor for the development of cardiovascular diseases (CVDs) which include atherosclerosis, coronary heart disease, and stroke. Although there are a large number of anti-hyperlipidemic drugs available, unfortunately, they all have side effects.
Terminalia chebula Retz. (Combretaceae) is a plant used to treat cardiac disorders in the traditional Ayurveda medicine in India. The objective of this study was to assess the anti-hyperlipidemic properties of a methanol (MeOH) bark extract of T. chebula.
Acute toxicity studies were performed according to the Organisation for Economic Cooperation and Development (OECD) guideline no. 423 using various doses (5, 50, 300, and 2000 mg/kg) of T. chebula bark. Anti-hyperlipidemic effect of MeOH bark extract of T. chebula at doses of 200, 400, and 600 mg/kg and fasting glucose levels after treatment with MeOH bark extract of T. chebula at doses of 200, 400, and 600 mg/kg were analyzed using commercially available kits.
Acute toxicity studies did not show any morbidity and mortality at various doses. The MeOH extract of T. chebula bark at doses of 200, 400, and 600 mg/kg significantly lowered serum cholesterol and triglyceride levels. Moreover, the extract of T. chebula and the positive control atorvastatin-treated groups of animals showed a significant increase in the serum high-density lipoprotein (HDL) cholesterol levels in diet-induced hypercholesterolemic animals.
The overall results confirm that the bark extract of T. chebula possesses significant anti-hyperlipidemic activity.
众所周知，高脂血症是心血管疾病（CVDs）发生的主要危险因素，心血管疾病包括动脉粥样硬化、冠心病和中风。尽管有大量抗高脂血症药物可用，但不幸的是，它们都有副作用。
诃子（使君子科）是印度传统阿育吠陀医学中用于治疗心脏疾病的一种植物。本研究的目的是评估诃子树皮甲醇提取物的抗高脂血症特性。
根据经济合作与发展组织（OECD）第423号指南，使用不同剂量（5、50、300和2000mg/kg）的诃子树皮进行急性毒性研究。使用市售试剂盒分析诃子树皮甲醇提取物在200、400和600mg/kg剂量下的抗高脂血症作用，以及在200、400和600mg/kg剂量下用诃子树皮甲醇提取物处理后的空腹血糖水平。
急性毒性研究在不同剂量下均未显示任何发病和死亡情况。诃子树皮甲醇提取物在200、400和600mg/kg剂量下显著降低了血清胆固醇和甘油三酯水平。此外，诃子提取物组和阳性对照阿托伐他汀治疗组的动物在饮食诱导的高胆固醇血症动物中血清高密度脂蛋白（HDL）胆固醇水平显著升高。
总体结果证实诃子树皮提取物具有显著的抗高脂血症活性。
