Roswall Nina, Li Yingjun, Kyrø Cecilie, Sandin Sven, Löf Marie, Adami Hans-Olov, Weiderpass Elisabete
Danish Cancer Society Research Center, Copenhagen, Denmark. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Department of Epidemiology and Health Statistics, Zhejiang University, Hangzhou, China.
Cancer Epidemiol Biomarkers Prev. 2015 Apr;24(4):755-7. doi: 10.1158/1055-9965.EPI-14-1314. Epub 2015 Jan 27.
Recently, the Nordic diet has gained interest, and a healthy Nordic food index has been developed, which has been found inversely related to colorectal cancer among Danish women. This single finding, however, requires replication in other cohorts.
We conducted a prospective study in the Women's Lifestyle and Health cohort, including 45,222 women, recruited in 1991-92, and followed up ever since through Swedish registries. Participants were classified according to the Nordic food index (consisting of whole grain bread, oatmeal, apples/pears, cabbages, root vegetables, and fish/shellfish), and the association between adherence and colorectal cancer was assessed using the Cox proportional hazards models.
In the fully adjusted models, we found no association, neither with the continuous index score [incidence rate ratio (IRR), 1.04; 95% confidence interval (CI), 0.95-1.12, per 1-point increment] nor in the categorical analyses (IRR, 1.09; 95% CI, 0.78-1.52 for highest vs. lowest adherers).
The present study does, thus, not support a previous finding of an inverse association between a healthy Nordic food index and colorectal cancer.
This article adds new evidence to the field of the Nordic diet in disease prevention.
最近，北欧饮食受到关注，并且已经开发出一种健康的北欧食物指数，研究发现该指数与丹麦女性的结直肠癌呈负相关。然而，这一单一发现需要在其他队列中进行重复验证。
我们在女性生活方式与健康队列中开展了一项前瞻性研究，该队列纳入了1991 - 1992年招募的45222名女性，此后通过瑞典登记系统进行随访。参与者根据北欧食物指数（包括全麦面包、燕麦片、苹果/梨、卷心菜、根茎类蔬菜以及鱼/贝类）进行分类，并使用Cox比例风险模型评估依从性与结直肠癌之间的关联。
在完全调整模型中，我们未发现关联，无论是连续指数评分（发病率比[IRR]为1.04；95%置信区间[CI]为0.95 - 1.12，每增加1分）还是分类分析（最高依从者与最低依从者相比，IRR为1.09；95% CI为0.78 - 1.52）。
因此，本研究不支持先前关于健康北欧食物指数与结直肠癌之间存在负相关的发现。
本文为北欧饮食在疾病预防领域增添了新的证据。
