Jones Harvey P, Testa Renee R, Ross Nola, Seal Marc L, Pantelis Christos, Tonge Bruce
School of Psychology and Psychiatry, Monash University, Clayton, VIC 3800, Australia ; Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, Carlton South, VIC 3053, Australia.
School of Psychology and Psychiatry, Monash University, Clayton, VIC 3800, Australia ; Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne, Carlton South, VIC 3053, Australia ; Child and Adolescent Neuropsychology Group, East Melbourne, VIC 3002, Australia.
Biomed Res Int. 2015;2015:635732. doi: 10.1155/2015/635732. Epub 2015 Jan 6.
Despite being identified as a high risk cohort for psychosis, there has been relatively little research on the clinical presentation and assessment of Schizotypal Personality Disorder (SPD) in childhood. The current study aimed to develop a measure of childhood SPD (Melbourne Assessment of Schizotypy in Kids (MASK)) and assess discriminant validity against another neurodevelopmental disorder, autism spectrum disorder (ASD). Sixty-eight children aged between 5 and 12 (21 SPD, 15 ASD, and 32 typically developing) and their parents were administered the MASK. The MASK is a 57-item semistructured interview that obtains information from the child, their parents, and the clinician. The results showed high internal consistency for the MASK and higher scores in the SPD group. A factor analysis revealed two MASK factors: social/pragmatic symptoms and positive schizotypal symptoms. Both factors were associated with SPD, while only the social/pragmatic factor was associated with ASD. Within the two clinical groups, a receiver operating characteristic curve showed that the MASK (cut-off score: 132 out of 228) was a good indicator of SPD diagnosis. These preliminary MASK findings were reliable and consistent and suggest that childhood SPD is characterised by complex symptomology distinguishable from ASD.
尽管分裂型人格障碍(SPD)被认定为精神病的高危群体,但针对儿童期SPD临床表现及评估的研究相对较少。本研究旨在开发一种儿童期SPD的测量工具(墨尔本儿童分裂型人格障碍评估量表(MASK)),并评估其相对于另一种神经发育障碍——自闭症谱系障碍(ASD)的判别效度。对68名年龄在5至12岁之间的儿童(21名患有SPD、15名患有ASD以及32名发育正常)及其父母进行了MASK测试。MASK是一个包含57个条目的半结构化访谈,从儿童、其父母以及临床医生处获取信息。结果显示,MASK具有较高的内部一致性,且SPD组得分更高。一项因子分析揭示了MASK的两个因子:社交/实用症状和阳性分裂型人格障碍症状。这两个因子均与SPD相关,而只有社交/实用因子与ASD相关。在两个临床组中,一条受试者工作特征曲线显示,MASK(临界分数:228分中的132分)是SPD诊断的良好指标。MASK的这些初步研究结果可靠且一致,表明儿童期SPD具有可与ASD区分的复杂症状特征。