人类主要组织相容性复合体I类基因家族的染色体组织
Chromosomal organization of the human major histocompatibility complex class I gene family.
作者信息
Koller B H, Geraghty D E, DeMars R, Duvick L, Rich S S, Orr H T
机构信息
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.
出版信息
J Exp Med. 1989 Feb 1;169(2):469-80. doi: 10.1084/jem.169.2.469.
Abstract
17 HLA class I genes have been isolated from the genome of B-lymphoblastoid cell line 721. Sequence analysis and transfection studies indicate that three genes, in addition to those encoding the HLA-A, -B, and -C antigens can direct the synthesis of a class I alpha protein (4, 5, 21). Using gene-specific DNA probes to analyze the presence of restriction fragment-length polymorphisms within a large pedigree and in panel of HLA deletion mutant cell lines, we show here that two of these genes, designated HLA-G and HLA-F, are located on the short arm of chromosome 6 telomeric to the HLA-A locus. The third expressed non-A, -B, and -C class I gene, HLA-E, is located between HLA-A and HLA-C (4). In addition, the remaining 11 class I pseudogenes and gene fragments are localized relative to established markers on chromosome 6p.
摘要
已从B淋巴母细胞系721的基因组中分离出17个HLA I类基因。序列分析和转染研究表明，除了编码HLA - A、- B和 - C抗原的基因外，还有三个基因可指导I类α蛋白的合成(4,5,21)。我们使用基因特异性DNA探针分析了一个大家族以及一组HLA缺失突变细胞系中限制性片段长度多态性的存在情况，结果表明，其中两个基因，即HLA - G和HLA - F，位于6号染色体短臂上HLA - A基因座的端粒位置。第三个表达的非A、非B和非C I类基因HLA - E位于HLA - A和HLA - C之间(4)。此外，其余11个I类假基因和基因片段相对于6号染色体短臂上已确定的标记进行了定位。
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