Sugaya Nagisa, Izawa Shuhei, Saito Keisuke, Shirotsuki Kentaro, Nomura Shinobu, Shimada Hironori
Department of Epidemiology and Public Health, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004 Japan.
Health Administration and Psychosocial Factor Research Group, National Institute of Occupational Safety and Health, 6-21-1 Nagao, Tama-ku, Kawasaki-shi, Kanagawa 214-8585 Japan.
Biopsychosoc Med. 2015 Jan 23;9(1):4. doi: 10.1186/s13030-015-0031-7. eCollection 2015.
The purpose of this study was to investigate the effect of prolonged stress on the salivary adrenal hormones (cortisol, dehydroepiandrosterone [DHEA], DHEA-sulfate [DHEA-S]) of individuals with irritable bowel syndrome (IBS).
The participants were female college students, including 10 with IBS and 16 without IBS (control group), who were scheduled for a 2-week teaching practice at a kindergarten. Participants were asked to collect saliva for determining adrenal hormones immediately and 30 min after awakening and before sleep, 2 weeks before the practice, the first week of the practice, the second week of the practice, and a few days after the practice.
Regarding cortisol/DHEA ratio, significantly increased levels were found during the first week of the practice, and a significant interaction between group and time was found; the ratio at 30 min after awakening in the IBS group was higher than that in the control group. For the other adrenal hormone indexes, no significant differences due to the presence of IBS were found.
Individuals with IBS showed an elevated cortisol/DHEA ratio after awakening compared with individuals without IBS, and the elevated ratio peaked under the prolonged stress. The present study suggests that the cortisol effect is dominant in individuals with IBS under prolonged stress.
本研究旨在调查长期应激对肠易激综合征（IBS）患者唾液肾上腺激素（皮质醇、脱氢表雄酮 [DHEA]、硫酸脱氢表雄酮 [DHEA-S]）的影响。
参与者为女大学生，其中10名患有IBS，16名无IBS（对照组），她们计划在幼儿园进行为期2周的教学实习。要求参与者在实习前2周、实习第一周、实习第二周以及实习后几天，在醒来后立即、醒来后30分钟以及睡前采集唾液以测定肾上腺激素。
关于皮质醇/DHEA比值，在实习第一周发现其水平显著升高，且发现组与时间之间存在显著交互作用；IBS组醒来后30分钟时的比值高于对照组。对于其他肾上腺激素指标，未发现因IBS的存在而有显著差异。
与无IBS的个体相比，IBS患者醒来后的皮质醇/DHEA比值升高，且该升高的比值在长期应激下达到峰值。本研究表明，在长期应激下，皮质醇效应在IBS患者中占主导地位。
