Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas.
Department of Pathology, Texas Children's Microbiome Center, Texas Children's Hospital, Houston, Texas.
Am J Physiol Gastrointest Liver Physiol. 2022 Jan 1;322(1):G1-G20. doi: 10.1152/ajpgi.00294.2021. Epub 2021 Nov 3.
The intricate connection between central and enteric nervous systems is well established with emerging evidence linking gut microbiota function as a significant new contributor to gut-brain axis signaling. Several microbial signals contribute to altered gut-brain communications, with steroids representing an important biological class that impacts central and enteric nervous system function. Neuroactive steroids contribute pathologically to neurological disorders, including dementia and depression, by modulating the activity of neuroreceptors. However, limited information is available on the influence of neuroactive steroids on the enteric nervous system and gastrointestinal function. In this review, we outline how steroids can modulate enteric nervous system function by focusing on their influence on different receptors that are present in the intestine in health and disease. We also highlight the potential role of the gut microbiota in modulating neuroactive steroid signaling along the gut-brain axis.
中枢神经系统和肠神经系统之间的复杂联系已经得到充分证实，越来越多的证据表明，肠道微生物群落的功能是肠道-大脑轴信号的一个重要新贡献者。几种微生物信号有助于改变肠道-大脑通讯，甾体代表了一个重要的生物学类别，影响中枢和肠神经系统的功能。神经活性甾体通过调节神经受体的活性，病理上导致包括痴呆和抑郁症在内的神经紊乱。然而，关于神经活性甾体对肠神经系统和胃肠道功能的影响的信息有限。在这篇综述中，我们通过关注甾体对健康和疾病中肠道中存在的不同受体的影响，概述了甾体如何调节肠神经系统功能。我们还强调了肠道微生物群在调节肠道-大脑轴上的神经活性甾体信号中的潜在作用。
