Department of Statistics, Chonnam National University, Gwangju, Korea.
Yonsei Med J. 2010 Mar;51(2):212-8. doi: 10.3349/ymj.2010.51.2.212. Epub 2010 Feb 12.
The present study was carried out to determine day-to-day differences in cortisol levels and the molar cortisol-to-dehydroepiandrosterone (DHEA) ratio (molar C/D ratio) in working subjects.
The cortisol and DHEA levels were measured from saliva samples collected 30 minutes after awakening for 7 consecutive days in full-time working subjects that worked Monday through Saturday. To determine the day-to-day differences within subjects, the collected data was analyzed using variance (ANOVA) for a randomized complete block design (RCBD).
The cortisol levels from samples collected 30 minutes after awakening on workdays were similar to each other, but were significantly different from the cortisol levels on Sunday. The DHEA levels were not significantly different between the days of week. The DHEA levels on Monday and Tuesday were relatively lower than the levels on the other weekdays. The DHEA levels on Thursday and Friday were relatively higher than the other days. The molar C/D ratios on Sunday were significantly lower than those on workdays. The molar C/D ratios on Monday and Tuesday were significantly higher than those on Wednesday or other workdays.
The cortisol levels and the molar C/D ratios demonstrate differences in adrenocortical activities between workdays and non-workdays, but the molar C/D ratio additionally represents differences in adrenocortical status between the first two workdays and other workdays. Thus, it is possible that the day-to-day differences in the cortisol levels and the molar C/D ratio represent the adrenal response to upcoming work-related stress.
本研究旨在确定工作日和非工作日之间皮质醇水平的日常差异以及皮质醇与脱氢表雄酮（DHEA）的摩尔比值（摩尔 C/D 比值）。
对全职工作者在连续 7 天每天早上醒来后 30 分钟收集的唾液样本进行皮质醇和 DHEA 水平检测，他们每周一至周六工作。为了确定个体内的日常差异，使用随机完全区组设计（RCBD）的方差（ANOVA）分析收集的数据。
工作日早上醒来 30 分钟后采集的皮质醇水平彼此相似，但与周日的皮质醇水平有显著差异。DHEA 水平在一周中的各天之间没有显著差异。周一和周二的 DHEA 水平相对低于其他工作日的水平。周四和周五的 DHEA 水平相对高于其他日子。周日的摩尔 C/D 比值明显低于工作日。周一和周二的摩尔 C/D 比值明显高于周三或其他工作日。
皮质醇水平和摩尔 C/D 比值显示了工作日和非工作日之间肾上腺皮质活动的差异，但摩尔 C/D 比值还反映了前两个工作日和其他工作日之间肾上腺皮质状态的差异。因此，皮质醇水平和摩尔 C/D 比值的日常差异可能代表了对即将到来的与工作相关的压力的肾上腺反应。
