运动在不同心脏肥厚性疾病中具有不同作用的证据。
Evidence for distinct effects of exercise in different cardiac hypertrophic disorders.
作者信息
Johnson Emily J, Dieter Brad P, Marsh Susan A
机构信息
Graduate Program in Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, USA.
Graduate Program in Movement Sciences, College of Education, University of Idaho, Moscow, ID, USA; Section of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA, USA.
出版信息
Life Sci. 2015 Feb 15;123:100-6. doi: 10.1016/j.lfs.2015.01.007. Epub 2015 Jan 26.
Abstract
Aerobic exercise training (AET) attenuates or reverses pathological cardiac remodeling after insults such as chronic hypertension and myocardial infarction. The phenotype of the pathologically hypertrophied heart depends on the insult; therefore, it is likely that distinct types of pathological hypertrophy require different exercise regimens. However, the mechanisms by which AET improves the structure and function of the pathologically hypertrophied heart are not well understood, and exercise research uses highly inconsistent exercise regimens in diverse patient populations. There is a clear need for systematic research to identify precise exercise prescriptions for different conditions of pathological hypertrophy. Therefore, this review synthesizes existing evidence for the distinct mechanisms by which AET benefits the heart in different pathological hypertrophy conditions, suggests strategic exercise prescriptions for these conditions, and highlights areas for future research.
摘要
有氧运动训练（AET）可减轻或逆转诸如慢性高血压和心肌梗死等损伤后发生的病理性心脏重塑。病理性肥厚心脏的表型取决于损伤类型；因此，不同类型的病理性肥厚可能需要不同的运动方案。然而，AET改善病理性肥厚心脏结构和功能的机制尚未完全明确，并且运动研究在不同患者群体中使用的运动方案高度不一致。显然需要进行系统研究，以确定针对不同病理性肥厚情况的精确运动处方。因此，本综述综合了现有证据，阐述了AET在不同病理性肥厚情况下对心脏有益的不同机制，提出了针对这些情况的策略性运动处方，并突出了未来研究的方向。
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