Madsen Christian, Durand Kevin L, Nafstad Per, Schwarze Per E, Rønningen Kjersti S, Håheim Lise L
Division of Epidemiology, Norwegian Institute of Public Health, PO Box 4404, Nydalen, Oslo, Norway.
Environ Res. 2008 Nov;108(3):354-60. doi: 10.1016/j.envres.2008.07.017. Epub 2008 Aug 30.
Cardiopulmonary morbidity and mortality is associated with several environmental exposures. Mechanistically, pathophysiological changes in the cardiopulmonary system may lead to the induction of inflammatory responses. In the present study we explored associations between environmental exposures and serum concentrations of lung Clara cell protein 16kDa, a biomarker that has recently been used to assess the integrity of the lung epithelium. Serum Clara cell protein concentrations were associated with both number of cigarettes smoked per day and number of pack-years of smoking. There was no evidence of an association between long-term exposure to ambient air pollution, as assessed at each participant's home address, and serum concentrations of CC16. However, short-term variations in both ambient air pollution and temperature were associated with increases in serum Clara cell concentrations. All findings were robust when other factors were adjusted for. These findings suggest that acute environmental exposures may compromise the integrity of the lung epithelium and lead to increased epithelial barrier permeability in the lungs of elderly men.
心肺疾病的发病率和死亡率与多种环境暴露因素相关。从机制上讲，心肺系统的病理生理变化可能会引发炎症反应。在本研究中，我们探讨了环境暴露与肺克拉拉细胞蛋白16kDa血清浓度之间的关联，该生物标志物最近被用于评估肺上皮的完整性。血清克拉拉细胞蛋白浓度与每日吸烟量和吸烟包年数均有关联。在每位参与者家庭住址处评估的长期暴露于环境空气污染与CC16血清浓度之间没有关联的证据。然而，环境空气污染和温度的短期变化与血清克拉拉细胞浓度的增加有关。在对其他因素进行调整后，所有结果均具有稳健性。这些发现表明，急性环境暴露可能会损害老年男性肺部上皮的完整性，并导致肺部上皮屏障通透性增加。
