食物过敏的诊断、管理及研究性治疗方法。
Diagnosis, management, and investigational therapies for food allergies.
作者信息
Kulis Mike, Wright Benjamin L, Jones Stacie M, Burks A Wesley
机构信息
Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
出版信息
Gastroenterology. 2015 May;148(6):1132-42. doi: 10.1053/j.gastro.2015.01.034. Epub 2015 Jan 26.
Food allergies have increased in prevalence over the past 20 years, now becoming an important public health concern. Although there are no therapies currently available for routine clinical care, recent reports have indicated that immunotherapies targeting the mucosal immune system may be effective. Oral immunotherapy is conducted by administering small, increasing amounts of food allergen; it has shown promise for desensitizing individuals with peanut, egg, or milk allergies. Sublingual immunotherapy also desensitizes allergic patients to foods-2 major studies have examined the effects of sublingual immunotherapy in subjects with peanut allergies. We review the complex nature of IgE-mediated food allergies and the therapies being evaluated in clinical trials. We focus on the diagnosis and management of food allergies and investigational therapies.
在过去20年中，食物过敏的患病率有所上升，现已成为一个重要的公共卫生问题。尽管目前尚无用于常规临床治疗的疗法，但最近的报告表明，针对黏膜免疫系统的免疫疗法可能有效。口服免疫疗法是通过给予少量且逐渐增加剂量的食物过敏原进行的；它已显示出对花生、鸡蛋或牛奶过敏的个体脱敏的前景。舌下免疫疗法也可使过敏患者对食物脱敏——两项主要研究已经考察了舌下免疫疗法对花生过敏受试者的影响。我们综述了IgE介导的食物过敏的复杂性质以及正在临床试验中评估的疗法。我们重点关注食物过敏的诊断和管理以及研究性疗法。
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