一种用于选择性检测和成像秀丽隐杆线虫内源性不稳定铁（III）池的双色比色荧光探针NAP-3。
A dual colorimetric-ratiometric fluorescent probe NAP-3 for selective detection and imaging of endogenous labile iron(III) pools in C. elegans.
作者信息
Goel Atul, Umar Shahida, Nag Pankaj, Sharma Ashutosh, Kumar Lalit, Hossain Zakir, Gayen Jiaur R, Nazir Aamir
机构信息
Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
出版信息
Chem Commun (Camb). 2015 Mar 25;51(24):5001-4. doi: 10.1039/c4cc09798j.
The discovery of an iron(III)-selective ratiometric fluorescent probe to detect and visualize endogenous labile iron pools in living organisms at the molecular level has been long awaited. Herein we report the first dual colorimetric and ratiometric fluorescent probe naphtho[2,1-b][1,10]phenanthroline for selective and 'direct' visualization of labile iron(III) pools in a multicellular organism, Caenorhabditis elegans.
长期以来，人们一直期待能够发现一种铁（III）选择性比率荧光探针，以便在分子水平上检测和可视化活生物体中的内源性不稳定铁池。在此，我们报告了首个用于多细胞生物秀丽隐杆线虫中不稳定铁（III）池的选择性和“直接”可视化的双色比色和比率荧光探针萘并[2,1-b][1,10]菲咯啉。
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