Ernst Timo, McCarthy Suzi, Chidlow Glenys, Luang-Suarkia Dagwin, Holmes Edward C, Smith David W, Imrie Allison
School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia.
PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia.
PLoS Negl Trop Dis. 2015 Jan 30;9(1):e0003442. doi: 10.1371/journal.pntd.0003442. eCollection 2015 Jan.
Dengue virus (DENV) transmission is ubiquitous throughout the tropics. More than 70% of the current global dengue disease burden is borne by people who live in the Asia-Pacific region. We sequenced the E gene of DENV isolated from travellers entering Western Australia between 2010-2012, most of whom visited Indonesia, and identified a diverse array of DENV1-4, including multiple co-circulating viral lineages. Most viruses were closely related to lineages known to have circulated in Indonesia for some time, indicating that this geographic region serves as a major hub for dengue genetic diversity. Most notably, we identified a new lineage of DENV-2 (Cosmopolitan genotype) that emerged in Bali in 2011-2012. The spread of this lineage should clearly be monitored. Surveillance of symptomatic returned travellers provides important and timely information on circulating DENV serotypes and genotypes, and can reveal the herald wave of dengue and other emerging infectious diseases.
登革病毒（DENV）传播在整个热带地区普遍存在。目前全球超过70%的登革疾病负担由生活在亚太地区的人承担。我们对2010年至2012年间进入西澳大利亚的旅行者所分离出的登革病毒E基因进行了测序，其中大多数人去过印度尼西亚，并鉴定出了多种不同的DENV1 - 4，包括多个共同传播的病毒谱系。大多数病毒与已知在印度尼西亚传播了一段时间的谱系密切相关，这表明该地理区域是登革病毒遗传多样性的主要中心。最值得注意的是，我们鉴定出了一种于2011年至2012年在巴厘岛出现的新型DENV - 2（泛基因型）谱系。该谱系的传播情况显然应受到监测。对有症状的归国旅行者进行监测可提供有关正在传播的登革病毒血清型和基因型的重要且及时的信息，并能揭示登革热及其他新发传染病的先兆。
