Zhang Jun, Ibrahim M M, Sun Mingzhong, Tang Jianwu
Department of Pathology, Dalian Medical University, Dalian 116044, China.
Department of Biotechnology, Dalian Medical University, Dalian 116044, China.
Clin Chim Acta. 2015 Aug 25;448:13-7. doi: 10.1016/j.cca.2015.01.020. Epub 2015 Jan 27.
Enoyl-CoA hydratase (Ech) catalyzes the second step in the physiologically important beta-oxidation pathway of fatty acid metabolism. The enzyme was reported to be associated with the progression, metastasis and drug resistance of cancers. It might function as a tumor promoter or a tumor suppressor for certain cancers depending on the particular type or stage of tumor cells/tissues. In this review, Ech's association with malignant tumors as well as its potential mechanisms is discussed and summarized. The enzyme might be useful in the diagnosis, treatment and prognosis determination of certain tumors.
烯酰辅酶A水合酶（Ech）催化脂肪酸代谢中生理上重要的β-氧化途径的第二步。据报道，该酶与癌症的进展、转移和耐药性有关。根据肿瘤细胞/组织的特定类型或阶段，它可能在某些癌症中作为肿瘤促进剂或肿瘤抑制因子发挥作用。在这篇综述中，讨论并总结了Ech与恶性肿瘤的关联及其潜在机制。该酶可能在某些肿瘤的诊断、治疗和预后判定中有用。
