癌细胞脂肪酸代谢的多样性和广度。

Nagarajan Shilpa R, Butler Lisa M, Hoy Andrew J

Discipline of Physiology, School of Medical Sciences, Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.

Cancer Metab. 2021 Jan 7;9(1):2. doi: 10.1186/s40170-020-00237-2.

Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular homeostasis. These attributes reflect the complex interactions between cell-intrinsic factors such as genomic-transcriptomic regulation and cell-extrinsic influences, including growth factor and nutrient availability. Alongside glucose and amino acid metabolism, fatty acid metabolism supports tumorigenesis and disease progression through a range of processes including membrane biosynthesis, energy storage and production, and generation of signaling intermediates. Here, we highlight the complexity of cellular fatty acid metabolism in cancer, the various inputs and outputs of the intracellular free fatty acid pool, and the numerous ways that these pathways influence disease behavior.

肿瘤细胞代谢具有显著特征，这些特征共同促进生物量合成，同时维持氧化还原平衡和细胞稳态。这些特性反映了细胞内在因素（如基因组-转录组调控）与细胞外在影响（包括生长因子和营养物质的可利用性）之间的复杂相互作用。除了葡萄糖和氨基酸代谢外，脂肪酸代谢通过一系列过程支持肿瘤发生和疾病进展，这些过程包括膜生物合成、能量储存和产生以及信号中间体的生成。在这里，我们强调癌症中细胞脂肪酸代谢的复杂性、细胞内游离脂肪酸池的各种输入和输出，以及这些途径影响疾病行为的多种方式。