Sakarya University, Medical School, Department of Pediatric Surgery, Sakarya, Turkey.
Sakarya University, Medical School, Department of Pediatric Surgery, Sakarya, Turkey.
Int J Surg. 2015 Mar;15:17-22. doi: 10.1016/j.ijsu.2015.01.022. Epub 2015 Jan 29.
BACKGROUNDS/AIMS: The aim of this study is to investigate the expected adhesion-modifying effect of clinoquinol which has metal-chelating feature that limits the inflammation and fibroblastic activity.
A total of 40 Wistar Albino rats were included, which were divided into 5 groups. Group-1 constituted the sham group. Other groups, adhesions were induced by performing cecal abrasion on the rats. For treatment, saline solution was added to Group-2, carboxymethylcellulose was added to Group-3, methylene blue was added to Group-4, and clioquinol was added to Group-5. Blood samples were obtained from the heart to measure IL-10 and TNF α-levels. Adhesions were evaluated both macroscopically and histopathologically.
Clioquinol reduced adhesions at significant level via decreasing the inflammation and fibroblastic activity in the adhesion-induced rats. At macroscopic level, carboxymethylcellulose and clioquinol were the most potent agents in reducing adhesions. Nonetheless, significant foreign body-reaction was observed in the carboxymethylcellulose-treated group.
Clioquinol could reduce the formation of intra-abdominal adhesions. It exerts this activity by limiting the inflammation and fibroblastic activity between the intestines and serous surfaces. Furthermore, it does not induce a foreign body reaction. Due to these properties, we conclude that clioquinol can be used as an alternative agent to prevent adhesions.
背景/目的：本研究旨在探讨氯碘喹啉的预期黏附改性作用，氯碘喹啉具有螯合金属的特性，可限制炎症和纤维母细胞活性。
共纳入 40 只 Wistar 白化大鼠，将其分为 5 组。第 1 组为假手术组。其他组通过对大鼠进行盲肠擦伤来诱导粘连。第 2 组加入生理盐水，第 3 组加入羧甲基纤维素，第 4 组加入亚甲蓝，第 5 组加入氯碘喹啉。从心脏抽取血液样本，以测量 IL-10 和 TNFα 水平。通过宏观和组织病理学评估粘连。
氯碘喹啉通过降低黏附诱导大鼠的炎症和纤维母细胞活性，显著降低了黏附程度。在宏观水平上，羧甲基纤维素和氯碘喹啉是减少粘连最有效的药物。然而，在羧甲基纤维素治疗组观察到明显的异物反应。
氯碘喹啉可减少腹腔内粘连的形成。它通过限制肠与浆膜表面之间的炎症和纤维母细胞活性来发挥这种作用。此外，它不会引起异物反应。由于这些特性，我们得出结论，氯碘喹啉可作为预防粘连的替代药物。
